Aim To observe the changes of hemorheology in the patients with cerebral infarction after hyperbaric oxygen (HBO) therapy. Methods 64 patients with cerebral infarction were randomly divided into the control group (drugs treatment only in 32 cases) and hyperbaric oxygen therapy group (hyperbaric oxygen plus drugs treatment in 32 cases), the hemorheological indexes were dectected before treatment and 12 days after treatment. Results The hemorheological indexes in hyperbaric oxygen therapy groups were all improved, those in hyperbaric oxygen therapy group after treatment were close to the normal level. While the hemorheological indexes in the control group were partly improved. Which were not more prominent than those in hyperbaric oxygen therapy group. Conclusion Hyperbaric oxygen therapy can improve the hemorheological indexes, according to the hemorheology to judge the curative effect of hyperbaric oxygen therapy.