Aim To study the clinical effect of Shuxuening injection on senile cerebral infarction. Methods 118 cases of senile cerebral infarction were randomly divided into two groups: 58 cases in treatment group were treated with Shuxuening injection, 60 cases in control group were treated with compound Salvia injection. Hemorrheological indexes were checked before and after therapy, the neurological deficit scale and curative effect of the two groups were compared. Results Hemorrhelogical indexes were significantly different in treatment group in using Shuxuening injection before and after therapy. In comparison with control group, hemorrheological indexes such as plasma viscosity, fibrinogen concentration of plasma, deformation index of red blood cell (RBC) and aggregation index of RBC were significantly different(p<0.05). The neurological deficit scale in treatment group were significantly lower than those in control group on the 14 th day after treatment, and more on the 21th day (p<0.01). On the 14 th day after treatment, the total effective rate of treatment group and control group was 86.2% and 68.3%. There is obvious difference in two groups of curative effect(p<0.05). Conclusions Shuxuening injection is efficient in treating senile celebral infarction just with very slight adverse effects, and provides selectable chance in the treatment of senile cerebral infarction.