Aim To study effects of acute normovolemic hemodilution(ANH) on hemodynamics,hemorheology,oxgen transport and consumption during Ileat-Golon Bladder Replacement Operation on coronary heart disease patierts. Methods Thirty-eight coronary heart disease patients(28 males,10 females) aged 41～63 years weighing 47～75 kg undergoing elective Ileat-Golon Bladder Replacement Operations were randomly divided into 2 groups with 19 patients in each group: ANH group and control group.Right internal jugular vein was cannulated with 7F Swan-Ganz floating cannula for central venous pressure(CVP) monitoring and blood sampling radial artery was cannulated blood pressure monitoring and blood gas analysis,femoral vein was cannulatel for blood sampling and fluid infusion.Blood(8～12 mL/kg) was removed from radial artery in ANH group and normovolemic was maintained by simultaneous infusion of 6% HEAS.Electrocardiogram(ECG),blood pressure(BP),central venous pressure were continuously monitored throughout the operation.Arterial and central venous blood samples were taken for blood gas analysis before and after ANH. Results There were no significant changes in heart rate(HR),mean arterial pressure(MAP),mean pulmonary artery pressure(MPAP),pulmonary capillary wedge pressure(PCWP) and CVP after ANH.There were no significant difference in parameters of blood gas analysis between two groups. Conclusion ANH can be safely used for coronary heart disease during Ileat-Golon Bladder Replacement Operations,and acute normovolemic hemodilution may have heart protection function.