Aim To investigate the effects of static magnetic field on proliferation,ultra-microstructure,apoptosis of human umbilical vascular endothelial cells. Methods The effects of static magnetics on proliferation of human umbilical vascular endothelial cells was observed by MTT;transmission electric microscopy was used to evaluate the ultra-microstructure of human umbilical vascular endothelial cells;apoptosis of human umbilical vascular endothelial cells was studied by flow cytometry and transmission electric microscopy. Results 0.05 mT magnetics can accelerate the proliferation of human umbilical vascular endothelial cells;0.1 mT magnetics have no effects on the growth of human umbilical vascular endothelial cells,however,magnetics of 1 mT,5 mT attenuate growth of human umbilical vascular endothelial cells.5 mT static magnetics could induce apoptosis and necrosis of human umbilical vascular endothelial cells. Conclusion The effects of static magnetics on human umbilical vascular endothelial cells is double edge-sword,5 mT static magnetic field does harm to human umbilical vascular endothelial cells.