Aim To study effects of cell protein phosphorylation on scavenger receptor.Methods Mouse peritoneal macrophages(MPM) were treated with protein kinase C(PCK) inhibitor staurosporine,and then the cell were incubated with ~(125) I-(oxidized low density lipoprotein(ox-LDL) or ox-LDL.The effects of the drug on expression of cell surface receptor were observed by means of autoradiography.Moreover,the cellular binding of ~(125) I-ox-LDL,its degradation and the accumulation of lipids within cell were measured separately.Results Staurosporine(0.4 μmol/L) could enhance MPM to bind lipids and stimulate scavenger receptor exression,and could reduce degradation of lipids by MPM and the accumulation of cholestrol within the cell.Conclusion The function of scavenger receptors may be correlated with cell protein phorsphorylation.