Aim To observe the effect of Pravastatin on plasma endothelin (ET), nitric oxide (NO)﹚ and C-reaction protein (CRP) in the early treatment of acute coronary syndromes (ACS). Methods 60 patients with ACS were randomly divided into the Pravastatin group (n=30) and the conventional medication group (n=30). The course of therapy was 2 weeks. The plasma concentration of ET, NO and CRP were measured before and after treatment. Results The levels of plasma CRP (32.7±10.8 μg/L), ET (50.3±17.2 μg/L) were lower and the level of NO (50.3±10.2 μmol/L) wes higher in the Pravastatin group than the levels of plasma CRP (44.3±9.7 μg/L), ET (72.4±16.4 μg/L), NO (42.8±8.7 μmol/L)in the conventional medication group (p<0.01). Conclusion Pravastatin can inhibit the inflammatory reaction so as to stabilize atherosclerotic plaque and improve endothelial function which relieve coronary artery spasm.