Aim To evalvate the effects of endovascular irradiation associated with simvastatin and clopidogrel on restenosis after interveneional therapy. Methods 72 male New Zealand white rabbits were studied. Except those in normal control group, other rabbits were made into athetoscletosis and restenosis modles. Immunohistochemistry method was used to detect the data expressed in the vascular. The expression were analyzed by image analysis. All these collected data were analyzed using factorial ANOVA. Results At each time point, the lumem area was larger and the neointima area was smaller in associated group than in other groups(p<0.05). The expression of matrix metalloproteinase-2(MMP-2), proliferation cell nuclear antigen(PCNA), α-SM actin in the vascular in the iliac arteries of associated group is the least (p<0.05). Conclusion 32 P irradiation associated with simvastatin and clopidogrel has the effect of preventing restenosis after balloon injury.