Aim To explore the microinflammatory state and the effect of microinflammatory response on lipoprotein(a)[Lp(a)] by analyzing chronic inflammatory indices and its correlation with Lp(a) in patients with maintained hemodialysis (MHD). Methods The serum chronic inflammatory indices including C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and Lp(a)were measured in 50 MHD patients and 30 normal controls, the relationship among them was analyzed. Results The serum CRP, IL-6, TNF-α and Lp (a) levels were 4.54±2.39 mg/L, 130.6±104.3 ng/L, 1.60 ±0.64 μg/L and 571.5±442.7 mg/L respectively in MHD group, and all of them were significantly higher in MHD group than those in control group. Lp(a) positively correlated with CRP, TNF-α and IL-6 (r values were 0.627, 0.486 and 0.404 respectively, each p<0.01). Conclusions There is microinflammatory state in MHD patients. Inflammation may correlate to metabolic disorder of Lp(a).