Aim To explore whether monocyte-derived macrophages and ECV304 endothelial cells express death-associated protein (Daxx) and expression induced by oxidative stress. Metheds Reverse transcription polymerase chain reaction (RT-PCR) were performed to detect Daxx mRNA expression in THP-1 monocyte-derived macrophages and ECV304 cells induced by ox-LDL and H 2O 2 respectively. Results THP-1 monocyte-derived macrophages and ECV304 cells expressed Daxx, Daxx mRNA expression increased after THP-1 monocyte-derived macrophages and ECV304 cells were incubated with ox-LDL (100 mg/L) and H 2O 2 (1 mmol/L) respectively. Conclusion Daxx may be involved in apoptosis induced by Oxidative stress in THP-1 monocyte-derived macrophages and ECV304 cells.