Aim To study the predictive value of inflammatory factors such as C-reactive protein (CRP), fibrinogen and tumor necrosis factor-α (TNF-α) in cardiac events of patients with acute coronary syndromes (ACS). Methods Seventy-six cases of ACS patients were tested of their blood concentrations of CRP, fibrinogen and TNF-α on the day of admission and followed for 7-12 months. Results Concentrations of CRP and fibrinogen in ACS patients were significantly raised compared with the controls, while that of TNF-α showed no difference compared with the controls. Patients who developed cardiac events had higher CRP and fibrinogen levels than those who survived free. Multivariate logistic regression analysis demonstrated CRP and fibrinogen were independent risk factors of ACS. Conclusions CRP and fibrinogen could predict cardiac events in ACS patients in short follow-up period, while TNF-α was of no use in predicting cardiac events in ACS patients.