Aim To investigate the changes of urinary ceruloplasmin excretion rate (CER) in the diseases with damage of blood vessels such as hypertension and diabetes. To compare the changes of urinary CER and albuminuria excretion rate (AER) and to evaluate the significance of them in clinical medicine. Methods The CER and AER levels were determined by the method of Enzyme Linked lmmunosorbent Assay respectively. Results In control group the CER mean value was 52.98 ±32.89 ng/min, and AER was 7.13±2.29 μg/min. In hypertension group CER mean value was 94.01±69.50 ng/min, and AER was 10.42±8.19 μg/min. In diabetes groups CER mean value was 131.92±103.64 ng/min, and AER was 18.69±27.3 μg/min. There were significant differences in both AER and CER, comparing control group with the hypertension and diabetes respectively (p<0.05). The CER and AER levels were highest in diabetes group. Conclusions ①The urinary CER of patients with diabetes and hypertension were higher than that in the control group. ②Compared CER of patients in different groups, the CER in diabetes group was highest of all with hypertension group followed. There were significant differences in CER and AER between groups of diabetes and hypertension. ③CER increased with the progression of AER in parallel.