Aim To explore the levels of neurotransmitter of sensory nerves and constrictor peptides of renin angiotensin system in renal vascular hyertensive rats, and the changes of these peptides after treatment with losartan or peridopril. Methods The 2 kidney, 1 cliped rats hypertensive model were used, and the plasma concentration of active peptides were determined by radioimmunoassay method. Results The plasma concentration of calcitonin gene related peptide (CGRP) was slightly raised in hypertensive rats, compared with sham operation group, and treatment with losartan or peridopril had markedly elevated plasma concentration of CGRP as well as angiotensin Ⅱ and rennin activity. Conclusions In the metaphase of renal vascular hypertension, the elevation of CGRP may be a compensation action due to increasing of blood pressure. Chronic treatment with losartan or peridopril not only affects the releasing of CGRP, but also activates the circular renin angiotensin system in renal vascular hypertension.