Aim To determine the serum cholesteryl ester transfer protein(CETP) level in patients with coronary heart disease(CHD) in Han nationality and explore its association with serum lipids, lipoproteins and apolipoproteins levels. Methods To undertake a case control study, we detected the serum CETP level in 64 unrelated healthy individuals and 106 patients with evidence of CHD by enzyme linked immunosorbent assay. Results The results showed that there was not statistically different between patients and controls(2.15±0.90 mg/L vs 2.31±1.08 mg/L ,p>0.05). No significant correlation was found between CETP concentration and lipids and lipoproteins concentration(p>0.05). Conclusions There is no significant relation between serum CETP level and CHD in Han nationality from northern China.