Influence of High Density Lipoprotein and Oxidized High Density Lipoprotein on Secretion of Nitric Oxide and Nitric Oxide Synthase and Endothelin 1 by ECV 304
Author:
  • Article
  • | |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • | |
  • Comments
    Abstract:

    Aim To investigate the influence of high density lipoprotein(HDL) and oxidized high density lipoprotein(ox HDL) on secretion of nitric oxide(NO),nitric oxide synthase(NOS),and endothelin 1(ET 1) by ECV 304;To provide evidence for protection effect of HDL on endothelial cells. Methods Different concentrations of HDL and ox HDL were used to treat human umbilical endothelial cell line ECV 304. NO, NOS and ET 1 secreted by ECV 304 were detected with corresponding kits respectively. Results The results indicated that HDL increased NO and NOS secreting,and decreased ET 1 secreting.On the contrary,ox HDL decreased NO and NOS level,and increased ET 1 level in ECV 304. Conclusions HDL might protect endothelial cells and antiatherosclerosis by increasing NO and NOS secreting and decreasing endothelin 1 secreting,but after oxidized such effects were lost.

    Reference
    Related
    Cited by
Get Citation

LIU Lu Shan, WEI Dang Heng ,,YANG Yong Zong . Influence of High Density Lipoprotein and Oxidized High Density Lipoprotein on Secretion of Nitric Oxide and Nitric Oxide Synthase and Endothelin 1 by ECV 304[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2002,10(5):421-423.

Copy
Related Videos

Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:May 23,2002
  • Revised:September 15,2002
Article QR Code