Aim To study the mechanism of Qing Yuan Tiao Zhi Capsule (QYTZC)decreasing blood-fat at the molecular level. Methods 27 Wistar rats were randomly divided into normal group (n=9), hyperlipemia group (n=9) and treatment group (n=9). In the experiment, all the rats from both hyperlipemia group and treatment group were daily fed with high fat feed for 8 days,with no limit to drinking except those from normal group, which were fed with ordinary feed. The rats in treatment group were given QYTZC (3 pellets for each, dissolved in water of 5 mL)by perfusion, twice a day after a week of the modeling. After the experiment, low density lipoprotein receptor (LDLR) mRNA was detected in the hepatic tissues of the rats from each group by reverse transcriptase-polymerase chain reaction (RT-PCR). Results QYTZC had a significant effect on LDLR gene expression of the rat (p<0.001). Conclusions QYTZC could increase LDLR gene expressin in rat hepatic tissues and, thus, decrease the level of blood-fat.