Lovastatin Down Regulates the Expression of Lectin-like Oxidized LowDensity Lipoprotein Receptor (LOX) 1mRNA on Human Umbilical Vein Endothelial Cells

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Lovastatin Down Regulates the Expression of Lectin-like Oxidized LowDensity Lipoprotein Receptor (LOX) 1mRNA on Human Umbilical Vein Endothelial Cells
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                        QUANZhi Hua1,LIQuan Zhong1,DENGHeng1,YIGuang Hui2 ,andYANGYong Zong2QUANZhi Hua1,LIQuan Zhong1,DENGHeng1,YIGuang Hui2 ,andYANGYong Zong2
1.DepartmentofCardiologyoftheFirstAffiliatedHospital, 2 .InstituteofCardiovascularDisease;NanhuaUniversity ,Hengyang 4 2 10 0 1,China
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Abstract:

Aim Toinvestigatewhetherstatinsaltertheexpressionoflectin likeoxidizedlowdensitylipoproteinreceptor (LOX) 1mRNA anduptakeofoxidizedlowdensitylipoproteinonculturedhumanumbilicalveinendothelialcells (hUVEC) . Methods TotalRNAwasextractedwithTrizolreagent. Reversetranscriptionpolymerasechainreaction (RT PCR)wasusedto quantifymRNAexpressionofLOX 1inhUVEC . Ox LDLwasradioiodinatedwith12 5 Itodetecttheuptakeofox LDLbyendothe lialcells. AspectrophotometricenzymeassaywasperformedtodeterminetheactivityofLDH . Results LOX 1mRNAexpressionwassignificantlysuppressedto 84 % ,6 9%and 4 8%ofcontrolafterhUVECwereincubated with 1,10 ,5 0 μmol/Loflovastatinfor4 8h. LOX 1mRNAexpressionwassignificantlysuppressedto 82 % ,6 9%and 5 2 %of controlinthecellstreatedwithlovastatinafter2 4 ,4 8or 96hrespectively . Conclusion LovastatinreducestheexpressionofLOX 1mRNAanduptakeofox LDLwithoutanytoxiceffectswhichmaycon tributetotheantiatheroscleroticpotentialoflovastatin .

Key words:Lovastatin;Endothelium ,Vascular;Lipoprotein ,LDL;Receptor,Lipoprotein

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QUANZhi Hua, LIQuan Zhong, DENGHeng, YIGuang Hui, andYANGYong Zong. Lovastatin Down Regulates the Expression of Lectin-like Oxidized LowDensity Lipoprotein Receptor (LOX) 1mRNA on Human Umbilical Vein Endothelial Cells[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2002,10(1):26-29.

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