Aim To investigate the preventive effect of V Flex stent implanted into coronary vessels on coronary arteriosclerosis disease. Methods One hundred and seventy four V Flex stents implantations were attempted in 124 patients (age 62.5±6.2) with 138 arteriosclerosis wounded vessels. Lesion types were A in 8 vessels, B in 86 vessels and C in 44 vessels. Acute angiographic success was 100%. Results Smooth angiographic results were obtained in all cages. Complications were one non stent related death, four non Q wave myocardial infarction. Six month control angiography was performed in 108 (27%) cases of eligible patients and revealed a restenosis rate of 24%. Conclusion Our study show that V Flex is an excellent coronary stent for treatment of complex lesions, providing excellent results with a low complication rate.