Aim To evaluate the safety, efficacy, angiographic and histopathological effects of a new 316L stainless steel tubular stent (V-Flex TM ) in a porcine coronary and peripheral artery model. Methods Stent implantation in the right coronary artery was successful in all 16 pigs. 8 pigs with V-Flex TM stent were angiophically treated after 6 weeks and then sacrificed, the remaining 8 pigs with V-Flex TM stent were angiophically controlled and sacrificed at 12 weeks. Then all vascular samples and angiographic films were analyzed morphologically. Results 6 week treated group showed only a mild fibromusclar neointimal hyperplasia of 1.15±0.38 mm 2. The neointimal hyperplasia was 1.22±0.34 mm 2 at 12 week controlled group, comparison with the Palmaz-Schatz coronary stent in a porcine peripheral artery model demonstrated significantly less neointimal hyperplasia at 6 weeks (1.11±0.73 mm 2 vs 2.40±0.36 mm 2,P<0.05)and at 12 weeks (1.53±0.42 mm 2 vs 2.47±0.63 mm 2,P<0.05), and also less in injury, inflammation and thrombus reaction at 6 and 12 weeks. Conclusion V-Flex TM coronary stent implantation in a porcine coronary and peripheral arteries results in a high procedural success and 12 weeks histopathological and morphologic evaluation demonstrated only a mild fibromuscular showed significantly less neointimal hyperplasia in the V-Flex TM stent.