The Synergistic Effect of Basic Fibroblast Growth Factor and Interleukin-6 on Rat Vascular Smooth Muscle Cell Proliferation
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    Abstract:

    Aim To observe the synergistic effect of basic fibroblast growth factor and interleukin-6 on vascular smooth muscle cells proliferation. Methods BrdU incorporation and cell counting method were adopted to observe the effects of basic fibroblast growth factor and interleukin-6 on the proliferation of rat aortic cultured smooth muscle cells. Results 0~10.0 μg/L basic fibroblast growth factor and 0~100 μg/L interleukin-6 were able to promote smooth muscle cells proliferation separately, and synergistically in combination in dose- and time-dependent manner. The pro-proliferation effect reached climax at 24 hours. Conclusion Basic fibroblast growth factor and interleukin-6 had synergistic effect on vascular smooth muscle cells proliferation.

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PAN Xiao-Hong, SHAN Jiang, ,LUO Jian-Hong ; [WT”HZ]. The Synergistic Effect of Basic Fibroblast Growth Factor and Interleukin-6 on Rat Vascular Smooth Muscle Cell Proliferation[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2000,8(3):233-236.

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History
  • Received:December 21,1999
  • Revised:July 05,2000
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