Aim The effect of bovine aortic heparan sulfate proteoglycan (HSPG), chondroitin sulfate proteoglycan (CSPG), dermatan chondroitin sulfate proteoglycan (DSCSPG) and mixed PG on the growth of cultured human aortic smooth muscle cells (hASMC) was studied in this article. Methods PGs were isolated by dissociative extraction, ion exchange chromatography and gel filtration from bovine aortic intima media and their effects on the growth of cultured hASMC were studied by cell count and 3 H TdR incorpor...