Aim To investigate the Protective effects of SK-827 on brain ischemia,/reperfusion (I/R )injury in rabbits.Methods Plasma lactate dehydrogenase (LDH) ac-tivity. malondialdehyde (MDA) content, lactate con-tent and brain ATP, MDA 1evel were assayed in I/Rgroup and SK-827 treated group.Results In SK-827 group, LDH activity, lactate content and MDA content in plasma and brain de-creased, ATP level in brain increased and encephalede-ma improved significantly as compared with I/Rgroup.Conclusion SK-827 might have protective effect onbrain I/R injury in rabbits.