Aim To investigate if platelet-derived growth fac-tor (PDGF-BB) is a chemoattr actant factor for mono-cytes adhesing vascular endothelium.Methods Pretreated with or without inflammatorymediators (tumor necrosis factor, 50 g/L;lipopolysaccharide 100 g/L) , the 51 Cr-labeled mono-cyte adhesion to endothelial cell (EC) monolayer wasassayed.Results PDGF-BB (1 , 10, 100 g/L) do not exerta direct influence on the monocyte adhesion to ECmonolayer, but it can potentiate the augmented effectof inflammatory mediators (tumor necrosis factor, 50g/L ; lipopolysaccharide , 100 g/L) on the monocyteadhesion.Conclusion PDGF-BB is by itself not a chemoat-tractant factor for MC, but can synergize the action ofsome monocyte active factors on monocyte adhesion tothe vascular endothelium.