Plasma concentration of lipoprotein(a) were measured by enzyme linked immunosorbentassay in 20 patients with coronary heart disease(CHD) and 20 healthy peoples. Plasma activity levelsof tissue type plasminogen activator (tPA) and plas-minogen activator inhibitor (PAI) were determined byspectrophotometric assay. Plasma concentration oflipoprotein (a) and activity of PAI in CHD group weresignificantly higher than the control group, however-plasma activity of tPA in CHD group were significant-ly lower. The plasma concentration of lipoprotein(a) in patients with CHD was not correlated with ac-tivity of tPA, but significantly positive correlated withactivity of PAI. It suggests that elevated plasmaconcentration of lipoprotein (a) is a risk factor forCHD. The results of this study showed also that plas-ma activity of tPA decrease and those of activity PAIof increase in the patients with CHD, which implythat reduced fibrinolytic capacity is related to CHD.High levels of lipoprotein (a) plasma may impair thefibrino1ytic system resueting in thrombose especiallyin the arterial system.