Aim Naoluotong (NLT) is a compound Chinesepreparation that to be used in the treatment ofatherosclerosis. In this study, the effect of Naoluo-tong is compared with that of the Gypenosides in clini-cal practice.Methods Thorgh double-blind clinical observation,the patients were divided into Naoluotong group andGypenoside group. A color ultrasonic Doppler blood-now acoustic image system(ultramark-9) was used todetect the atherosclerosis plaque in the bilateralcarotid, measure the cervrical artery intima-media tu-nica thickness(CAIMT) and determine blood lipid, su-peroxide dismutase (SOD), lipid peroxide (LPO) andindexes of blood rheology. Part of the patients also hadtheir blood platelet aggregation rate (PAR) and heartfunction examined- Blood and urine routine and liverand kidney function examinations were conducted so asto find out about the safety of the medicine.Results Among the 57 patients with atherosclerosisplaques in the Naoluotong group, disappearance of theplaques occurred in 15. 8% (9/57), reduced plaquesoccurred in 47. 4K (27/57) and unchanged plaques oc-curred in 29. 8K (17/57) of the patients, the total effective rate being 93K (53/57). The total effective rateobtained in the Naoluotong group in resolving plaqueand reducing the cross section area was much higherthan that in the Gypenoside group (p<0. 01 or 0. 05).It was found that Naoluotong could reduce the thick-ness of the thickened tunica intima-media and had bet-ter effect than Gypenosides in reducing total choles-terol (TC ), triglycerides (TG ) and low densitylipoprotein cholesterol (LDLC) ; raising SOD and re-ducing LPO; and in reducing whole blood viscosity,fibringoen, packed cell volume, blood platelet maxi-mum aggregation rate, etc.Conclusion Naoluotong has better therapeutic effect than the total glycoside in Gypenoside treatingatherosclerosis, in that it can prevent the disease fromprogressing further and may even resolve the plaquesformedas a result of atherosclerosis.