Endothelial injury and thrombosis are essential events initiating restenosis after ballooning argioplasty. An arterial stenosis model was estabished in New Zealand rabbits by external crushing of the ear central artery. Vascular endo-thelial growth tactor and hirudin were injected subcutaneously in the vicinity of and retorgrade, intra-arterially distal to the crushing sits. The cross-sectional percentage of stenosis, calculated by measuring the areasof the patent lumen and neointima on sections with the most prominent smooth muscle cell hyperplasis, was compared between the study group and control group.No signiticant difference was found (P > 0. 05 ). The faiture of the treatment was discussed.