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昼夜节律和时钟基因在动脉粥样硬化发生中的作用机制研究进展
作者:
作者单位:

(北京医院 国家老年医学中心 国家卫生健康委北京老年医学研究所 国家卫生健康委老年医学重点实验室中国医学科学院老年医学研究院,北京市100730)

作者简介:

李汶霖,硕士研究生,研究方向为心血管疾病发病机制,E-mail:1044735985@qq.com。

基金项目:

国家自然科学基金项目(81770228、82370584)；北京市自然科学基金项目(7232141)


The progress of the role and mechanisms of circadian rhythm and clock gene in the development of atherosclerosis
Author:
  • LI Wenlin

    LI Wenlin

    Beijing Hospital & National Geriatrics Center & Beijing Institute of Geriatrics of the National Health Commission & Beijing Key Laboratory of Geriatrics of the National Health Commission & Institute of Geriatrics of the Chinese Academy of Medical Sciences, Beijing 100730, China
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  • LI Sainan

    LI Sainan

    Beijing Hospital & National Geriatrics Center & Beijing Institute of Geriatrics of the National Health Commission & Beijing Key Laboratory of Geriatrics of the National Health Commission & Institute of Geriatrics of the Chinese Academy of Medical Sciences, Beijing 100730, China
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  • YANG Yao

    YANG Yao

    Beijing Hospital & National Geriatrics Center & Beijing Institute of Geriatrics of the National Health Commission & Beijing Key Laboratory of Geriatrics of the National Health Commission & Institute of Geriatrics of the Chinese Academy of Medical Sciences, Beijing 100730, China
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  • MA Qinan

    MA Qinan

    Beijing Hospital & National Geriatrics Center & Beijing Institute of Geriatrics of the National Health Commission & Beijing Key Laboratory of Geriatrics of the National Health Commission & Institute of Geriatrics of the Chinese Academy of Medical Sciences, Beijing 100730, China
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  • HUANG Xiuqing

    HUANG Xiuqing

    Beijing Hospital & National Geriatrics Center & Beijing Institute of Geriatrics of the National Health Commission & Beijing Key Laboratory of Geriatrics of the National Health Commission & Institute of Geriatrics of the Chinese Academy of Medical Sciences, Beijing 100730, China
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  • DOU Lin

    DOU Lin

    Beijing Hospital & National Geriatrics Center & Beijing Institute of Geriatrics of the National Health Commission & Beijing Key Laboratory of Geriatrics of the National Health Commission & Institute of Geriatrics of the Chinese Academy of Medical Sciences, Beijing 100730, China
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  • LIU Deping

    LIU Deping

    Beijing Hospital & National Geriatrics Center & Beijing Institute of Geriatrics of the National Health Commission & Beijing Key Laboratory of Geriatrics of the National Health Commission & Institute of Geriatrics of the Chinese Academy of Medical Sciences, Beijing 100730, China
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  • LI Jian

    LI Jian

    Beijing Hospital & National Geriatrics Center & Beijing Institute of Geriatrics of the National Health Commission & Beijing Key Laboratory of Geriatrics of the National Health Commission & Institute of Geriatrics of the Chinese Academy of Medical Sciences, Beijing 100730, China
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  • SHEN Tao

    SHEN Tao

    Beijing Hospital & National Geriatrics Center & Beijing Institute of Geriatrics of the National Health Commission & Beijing Key Laboratory of Geriatrics of the National Health Commission & Institute of Geriatrics of the Chinese Academy of Medical Sciences, Beijing 100730, China
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Affiliation:

Beijing Hospital & National Geriatrics Center & Beijing Institute of Geriatrics of the National Health Commission & Beijing Key Laboratory of Geriatrics of the National Health Commission & Institute of Geriatrics of the Chinese Academy of Medical Sciences, Beijing 100730, China)

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    摘要:

    随着全球人口寿命的延长和老龄化问题的日益严峻,心血管疾病已经成为老龄化人群的主要死亡原因。心血管疾病大多起源于动脉粥样硬化斑块的形成。除了常见的危险因素,如血脂异常、糖尿病、高血压、吸烟和肥胖外,昼夜节律的紊乱也被视为动脉粥样硬化的一个重要但常被忽视的危险因素。昼夜节律参与调节炎症和代谢等关键生理过程,进而影响动脉硬化和血栓形成的病理过程。在这一过程中,维持昼夜节律稳定的关键基因,即时钟基因,扮演着至关重要的角色。时钟基因在动脉粥样硬化的病理机制中具有重要作用,它们有可能成为预防和治疗动脉粥样硬化的潜在新靶点。本文综述了时钟基因在动脉粥样硬化发生和发展中的作用机制的最新研究进展,这些发现可能为动脉粥样硬化的诊断和治疗提供新的思路。

    Abstract:

    With the extension of the global population's lifespan and the increasingly severe aging problem, cardiovascular diseases have become the leading cause of death among the elderly population. Most cardiovascular diseases originate from the formation of atherosclerotic plaques. In addition to common risk factors such as dyslipidemia, diabetes, hypertension, smoking, and obesity, circadian rhythm disruption is also regarded as an important but often overlooked risk factor for atherosclerosis. The circadian rhythm is involved in regulating key physiological processes such as inflammation and metabolism, which in turn affect the pathological processes of arteriosclerosis and thrombosis. In this process, the key genes that maintain the stability of the circadian rhythm, namely clock gene, play a crucial role. Clock gene have an important role in the pathological mechanism of atherosclerosis, and they may become potential new targets for the prevention and treatment of atherosclerosis. This paper reviews the latest research progress on the mechanism of action of clock gene in the occurrence and development of atherosclerosis. These findings may provide new ideas for the diagnosis and treatment of atherosclerosis.

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引用本文

李汶霖,李赛男,杨尧,马启楠,黄秀清,窦琳,刘德平,黎健,沈涛.昼夜节律和时钟基因在动脉粥样硬化发生中的作用机制研究进展[J].中国动脉硬化杂志,2025,33(5):369~377.

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  • 收稿日期:2024-05-13
  • 最后修改日期:2024-07-09
  • 在线发布日期: 2025-06-03

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