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铁死亡在代谢性心血管疾病中的作用
作者:
作者单位:

(1.首都医科大学基础医学院,北京市 100069;2.首都医科大学基础医学院生理学与病理生理学系,北京市 100069 ;3.代谢紊乱相关心血管疾病北京市重点实验室,北京市 100069)

作者简介:

孔湘柠,研究方向为代谢紊乱与心血管衰老,E-mail:ning_0424@qq.com。通信作者王雯,博士,教授,博士研究生导师,研究方向为代谢紊乱相关心血管疾病的发病机制及干预,E-mail:wangwen@ccmu.edu.cn。

基金项目:

国家自然科学基金项目(91839107)


The role of ferroptosis in metabolic cardiovascular diseases
Author:
Affiliation:

1.School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China;2.Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University,Beijing 100069, China ;3.Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Beijing 100069, China)

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    摘要:

    铁死亡是一种程序性细胞死亡方式,其特征是细胞亚铁离子及大量脂质过氧化物的积累。代谢性心血管疾病是由一系列代谢因素参与的以心血管功能损害为特征的疾病。越来越多的研究表明铁死亡在代谢性心血管疾病的发生发展中发挥着重要的作用。探究铁死亡在代谢性心血管疾病中的作用,对揭示代谢性心血管疾病的发病机制和防治策略具有重要的临床意义。

    Abstract:

    Ferroptosis is a form of programmed cell death, which is characterized by the accumulation of ferrous irons and a large number of lipid peroxides in cells. Metabolic cardiovascular diseases are characterized by cardiovascular dysfunction involving a series of metabolic factors. More and more studies have shown that ferroptosis plays an important role in the occurrence and development of metabolic cardiovascular diseases. Therefore, exploring the role of ferroptosis in metabolic cardiovascular diseases has vital clinical significance for revealing the pathogenesis and prevention strategies of metabolic cardiovascular diseases.

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孔湘柠,兰玥,严文静,王雯.铁死亡在代谢性心血管疾病中的作用[J].中国动脉硬化杂志,2023,31(5):369~374.

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  • 收稿日期:2022-12-20
  • 最后修改日期:2023-02-02
  • 在线发布日期: 2023-05-19

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