2025年7月14日 周一
首页 > 按月查看>2023年第3月 >199-204, 244. DOI:10.20039/j.cnki.1007-3949.2023.03.003
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代谢重编程:单核/巨噬细胞训练免疫参与动脉粥样硬化的新机制
作者:
作者单位:

(1.北京医院 国家老年医学中心 国家卫生健康委北京老年医学研究所 国家卫生健康委老年医学重点实验室 中国医学科学院老年医学研究院,北京市 100730;2.北京大学第五临床医学院,北京市 100730)

作者简介:

杨尧,硕士研究生,研究方向为心血管疾病发病机制,E-mail:yangyao405@163.com。通信作者沈涛,研究员,研究方向为心血管疾病发病机制,E-mail:shentao4189@bjhmoh.cn。通信作者黎健,博士,教授,博士研究生导师,主要从事糖脂代谢紊乱、衰老与老年相关疾病发病机制的研究,E-mail:lijian@bjhmoh.cn。

基金项目:

国家自然科学基金项目(81770228、81600618和81770858)


Metabolic reprogramming:a novel mechanism of monocyte/macrophage trained immunity in atherosclerosis
Author:
  • YANG Yao 1

    YANG Yao

    The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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  • YAN Mingjing 1,2

    YAN Mingjing

    The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;Peking University Fifth School of Clinical Medicine, Beijing 100730, China
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  • XU Kun 1

    XU Kun

    The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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  • SUN Shenghui 1

    SUN Shenghui

    The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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  • LI Wenlin 1

    LI Wenlin

    The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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  • DOU Lin 1

    DOU Lin

    The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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  • HUANG Xiuqing 1

    HUANG Xiuqing

    The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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  • TANG Weiqing 1

    TANG Weiqing

    The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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  • LI Jian 1,2

    LI Jian

    The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;Peking University Fifth School of Clinical Medicine, Beijing 100730, China
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  • SHEN Tao 1,2

    SHEN Tao

    The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;Peking University Fifth School of Clinical Medicine, Beijing 100730, China
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Affiliation:

1.The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;2.Peking University Fifth School of Clinical Medicine, Beijing 100730, China)

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    摘要:

    动脉粥样硬化是血管的慢性炎症性疾病,单核/巨噬细胞的异常活化与动脉粥样硬化的发生发展密切相关。近期研究发现单核/巨噬细胞可以通过训练免疫发生代谢重编程,促进炎症反应,加快动脉粥样硬化的进展,并可以导致心血管意外事件的发生。文章综述了单核/巨噬细胞代谢重编程在训练免疫发生中的作用和机制,可能为动脉粥样硬化的防治提供新的治疗靶点和方法。

    Abstract:

    Atherosclerosis is a chronic inflammatory disease of artery. Abnormal activation of monocytes/macrophages is closely related to the development of atherosclerosis. Recent studies have found that monocytes/macrophages can undergo metabolic reprogramming by trained immunity, promote inflammatory responses, which accelerate the progression of atherosclerosis and increase cardiovascular incidents. In this review, we discuss the function and mechanisms of metabolic reprogramming of monocytes/macrophages in the trained immunity, which may provide new therapeutic targets and methods for the prevention and treatment of atherosclerosis.

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引用本文

杨尧,闫明静,徐昆,孙升辉,李汶霖,窦琳,黄秀清,唐蔚青,黎健,沈涛.代谢重编程:单核/巨噬细胞训练免疫参与动脉粥样硬化的新机制[J].中国动脉硬化杂志,2023,31(3):199~204, 244.

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  • 收稿日期:2022-06-29
  • 最后修改日期:2022-09-19
  • 在线发布日期: 2023-03-24

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