2025年6月24日 周二
首页 > 按月查看>2023年第1月 >63-69. DOI:10.20039/j.cnki.10073949.2023.01.009
PDF 导出
脉压指数联合动脉硬化指数对冠心病患者冠状动脉病变严重程度的预测价值
作者:
作者单位:

(佛山市中医院心内科,广东省佛山市 528000)

作者简介:

彭毅,硕士,副主任医师,研究方向为冠心病,E-mail:pdvarw@163.com。通信作者赵华云,硕士,主任医师,研究方向为冠心病,E-mail:54pengyi@163.com。

基金项目:

佛山市卫生健康局医学科研课题(20200240)；广东省中医药局科研项目(20203009)


Predictive value of pulse pressure index combined with arteriosclerosis index on coronary artery disease severity in patients with coronary heart disease
Author:
Affiliation:

Department of Cardiology, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong 528000, China)

  • 摘要
    • | |
  • 访问统计
    • |
  • 参考文献
    • |
  • 相似文献
    • | |
    摘要:

    目的]探讨脉压指数(PPI)联合动脉硬化指数(AI)对冠心病患者冠状动脉病变严重程度的预测价值。 [方法]选取2019年1月—10月在佛山市中医院经冠状动脉造影(CAG)检查诊断为冠心病的150例患者,分为单支组(36例)、双支组(49例)、三支组(65例)；同期行CAG后排除冠心病的患者50例纳入对照组。冠心病分型:稳定型心绞痛(SAP)患者37例、不稳定型心绞痛(UAP)患者42例、急性非ST段抬高型心肌梗死(NSTEMI)患者35例、急性ST段抬高型心肌梗死(STEMI)患者36例。比较各组PPI、AI水平差异,并分析冠心病患者冠状动脉病变严重程度的影响因素。Gensini评分与PPI、AI水平的相关性采用Pearson分析。PPI、AI预测冠状动脉病变严重程度的效能采用ROC曲线分析。 [结果]单支组、双支组及三支组PPI、AI水平依次增加(P＜0.05)。SAP组、UAP组、NSTEMI组及STEMI组PPI、AI水平相比差异无统计学意义(P＞0.05)。PPI、AI均与Gensini评分存在正相关(r＝0.561、r＝0.629,均P＝0.000)。多因素Logistic回归显示,PPI、AI是冠心病发病的危险因素,PPI、AI以及Gensini评分是冠状动脉三支病变的影响因素(P＜0.05)。PPI、AI预测冠心病的ROC曲线下面积(AUC)为0.809、0.899,PPI联合AI预测冠心病的AUC为0.937；PPI、AI分别预测冠状动脉三支病变的AUC为0.893、0.917,PPI联合AI预测冠状动脉三支病变的效能较大,AUC为0.969。 [结论]PPI、AI与冠心病患者冠状动脉病变严重程度密切相关,PPI联合AI对冠心病患者冠状动脉病变严重程度有较高的预测价值。

    Abstract:

    Aim To investigate the predictive value of pulse pressure index (PPI) combined with arteriosclerosis index (AI) on coronary artery disease severity in patients with coronary heart disease (CHD). Methods A total of 150 patients who were diagnosed with CHD after coronary angiography (CAG) in Foshan Hospital of Traditional Chinese Medicine from January 2019 to October 2019 were selected and grouped into single-branch group (36 cases), double-branch group (49 cases), and three-branch group (65 cases); fifty patients without CHD after CAG recurrently were included in the control group. CHD classification:37 cases in stable angina pectoris (SAP) group, 42 cases in unstable angina pectoris (UAP) group, 35 cases in non-ST segment elevation myocardial infarction (NSTEMI) group, ST segment elevation myocardial infarction (STEMI) group of 36 cases. The differences in PPI and AI levels among each groups were compared, and the influencing factors of coronary artery disease severity in CHD patients were analyzed. The correlation between Gensini score and PPI and AI level was analyzed by Pearson analysis. The efficacy of PPI and AI in predicting coronary artery disease severity was analyzed by ROC curve. Results The levels of PPI and AI in the single-branch group, double-branch group, and three-branch group increased sequentially (P＜0.05). Compared with the SAP group, UAP group, NSTEMI group and STEMI group, there was no significant difference in PPI and AI levels (P＞0.05). Both PPI and AI were positively correlated with Gensini score (r＝0.561, r＝0.629, both P＝0.000). Multivariate Logistic regression showed that PPI and AI were the risk factors for CHD, and PPI, AI and Gensini score were the influencing factors of three-branch coronary artery disease (P＜0.05). The area under curve (AUC) of PPI and AI to predict CHD was 0.809 and 0.899, respectively, and the AUC of PPI combined with AI to predict CHD was 0.937. The AUC of PPI and AI for predicting three-branch coronary artery disease was 0.893 and 0.917, respectively, the PPI combined with AI had higher efficacy in predicting three-branch coronary artery disease, with an AUC of 0.969. Conclusion PPI and AI are closely related to severity of coronary artery disease in CHD patients. PPI combined with AI has high predictive value for coronary artery disease severity in CHD patients.

    参考文献
    [1] SAADATAGAH S, PASHA A K, ALHALABI L, et al.Coronary heart disease risk associated with primary isolated hypertriglyceridemia:a population-based study.J Am Heart Assoc, 1,0(11):e019343.
    [2] SONG C, WU G, CHANG S, et al.Plasma P-selectin level is associated with severity of coronary heart disease in Chinese Han population.J Int Med Res, 0,8(6):1-8.
    [3] 章琪, 罗玉寅.血清ApoB/ApoA1、CK-MB、cTnI水平与冠心病患者冠状动脉狭窄程度的关系.中国动脉硬化杂志, 1,9(10):875-878.ZHANG Q, LUO Y Y.The relationship between the levels of ApoB/ApoA1, CK-MB, cTnI and the degree of coronary artery stenosis in patients with coronary heart disease.Chin J Arterioscler, 1,9(10):875-878.
    [4] GUO F, SHA Y, HU B, et al.Correlation of long non-coding RNA lncRNA-FA2H-2 with inflammatory markers in the peripheral blood of patients with coronary heart disease.Front Cardiovasc Med, 1,8(1):1-10.
    [5] 崔露露, 商黔惠, 王晓春, 等.高血压患者脉压与早期动脉粥样硬化指标的关系.中国老年学杂志, 9,9(19):4625-4631.CUI L L, SHANG Q H, WANG X C, et al.The correlation between pulse pressure and early arteriosclerosis index in patients with hypertension.Chin J Gerontol, 9,9(19):4625-4631.
    [6] 侯冰洁, 高立伟, 李萌, 等.冠心病患者脉压及脉压指数与缺血性卒中预后的关系.中国分子心脏病学杂志, 9,9(5):3058-3060.HOU B J, GAO L W, LI M, et al.Relationship between pulse pressure and pulse pressure index of ischemic stroke in patients with coronary heart disease.Mol Cardiol Chin, 9,9(5):3058-3060.
    [7] 王君君, 章帆, 姜丰, 等.动脉粥样硬化指数与血清抗心磷脂抗体及抗β2糖蛋白1抗体水平的相关性研究.中国动脉硬化杂志, 9,7(7):611-614.WANG J J, ZHANG F, JIANG F, et al.Study on the correlation between atherogenic index and serum anti-cardiolipin anti-body and anti-β2 glycoprotein 1 antibody levels.Chin J Arterioscler, 9,7(7):611-614.
    [8] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会.中国心血管病预防指南.中华心血管病杂志, 1,9(1):3-22.CHINESE SOCIETY OF CARDIOLOGY, EDITORIAL BOARD OF CHINESE JOURNAL OF CARDIOVASCULAR.Chinese guidelines for prevention of cardiovascular diseases.Chin J Cardiol, 1,9(1):3-22.
    [9] 管文娟, 牛锁成.冠心病患者外周血miR-21的表达及与冠状动脉病变程度的关系.中国老年学杂志, 7,7(2):376-378.GUAN W J, NIU S C.Expression of miR-21 in peripheral blood of patients with coronary heart disease and its relationship with the degree of coronary artery disease.Chin J Gerontol, 7,7(2):376-378.
    [10] WU Y, WANG L, ZHAN Y, et al.The expression of SAH, IL-1β, Hcy, TNF-α and BDNF in coronary heart disease and its relationship with the severity of coronary stenosis.BMC Cardiovasc Disord, 2,2(1):101-105.
    [11] ZHANG Z, WANG L, ZHAN Y, et al.Clinical value and expression of Homer 1, homocysteine, S-adenosyl-l-homocysteine, fibroblast growth factors 23 in coronary heart disease.BMC Cardiovasc Disord, 2,2(1):215-223.
    [12] ZANG J, LIANG J, ZHUANG X, et al.Intensive blood pressure treatment in coronary artery disease:implications from the systolic blood pressure intervention trial (SPRINT).J Hum Hypertens, 2,6(1):86-94.
    [13] 司月乔, 丁振江, 王文丰, 等.不同性别患者肱动脉脉压升高与冠心病患病风险的关系.中华医学杂志, 0,0(23):1816-1819.SI Y Q, DING Z J, WANG W F, et al.Correlation between elevation of brachial artery pulse pressure increased and coronary heart disease in different genders.Natl Med J China, 0,0(23):1816-1819.
    [14] RAINA R, POLACONDA S, NAIR N, et al.Association of pulse pressure, pulse pressure index, and ambulatory arterial stiffness index with kidney function in a cross-sectional pediatric chronic kidney disease cohort from the CKiD study.J Clin Hypertens (Greenwich), 0,2(6):1059-1069.
    [15] 高砚丽, 康黎, 张莹.老年高血压患者认知功能损害与血压变异性、昼夜动脉血压情况、脉压指数的相关性.实用临床医药杂志, 0,4(3):56-60.GAO Y L, KANG L, ZHANG Y.Correlation between blood pressure variability, circadian arterial blood pressure, pulse pressure index and cognitive impairment in elderly patients with hypertension.J Clin Med Pract, 0,4(3):56-60.
    [16] 龚心文, 蔡海军, 雷英.高血压患者动态脉压和脉压指数与并发冠心病的关系.中国心血管病研究, 0,8(5):413-417.GONG X W, CAI H J, LEI Y.Relationship between dynamic pulse pressure and pulse pressure index and coronary heart disease in patients with hypertension.Chin J Cardiovasc Rev, 0,8(5):413-417.
    [17] 辛仰勋, 范虞琪, 顾俊, 等.脉压、脉压指数与冠状动脉钙化程度的关系研究.心血管康复医学杂志, 0,9(5):531-536.XIN Y X, FAN Y Q, GU J, et al.Relationship among pulse pressure, pulse pressure index and coronary artery calcification severity.Chin J Cardiovasc Rehabil Med, 0,9(5):531-536.
    [18] 马杰, 马千里, 廖红娟, 等.TM水平在冠心病患者冠状动脉旁路移植术围术期改变及与动脉硬化指数的关系.分子诊断与治疗杂志, 2,4(2):295-298.MA J, MA Q L, LIAO H J, et al.The relationship between TM level in the perioperative period of coronary artery bypass grafting and arteriosclerosis index in patients with coronary heart disease.J Mol Diagn Ther, 2,4(2):295-298.
    [19] 缐海英, 刘小娟.氨氯地平联合氯沙坦钾治疗高血压合并高尿酸血症血尿酸、尿微量蛋白及动脉硬化指数的分析.中西医结合心脑血管病杂志, 0,8(15):2495-2497.MIAN H Y, LIU X J.Analysis of amlodipine combined with losartan potassium in the treatment of hypertension complicated with hyperuricemia, serum uric acid, urine microprotein and arteriosclerosis index.Chin J Integr Med Cardio-Cerebrovasc Dis, 0,8(15):2495-2497.
    [20] 金雷, 王晓宇, 陈忠锐.冠心病患者血清non-HDL-C、动脉粥样硬化指数与冠状动脉狭窄程度的关系研究.中国循证心血管医学杂志, 9,1(2):175-177.JIN L, WANG X Y, CHEN Z R.Relationship between serum non-HDL-C, atherosclerosis index and severity of coronary artery stenosis in patients with coronary atherosclerotic heart disease.Chin J Evid Based Cardiovasc Med, 9,1(2):175-177.
    [21] 徐方艳, 韩子华, 付华美, 等.动脉粥样硬化指数和血小板参数在血脂异常痰浊阻遏证中的临床意义.中华中医药学刊, 1,9(4):244-247.XU F Y, HAN Z H, FU H M, et al.Clinical significance of atherosclerosis index and parameters in dyslipidemia.Chin Arch Tradit Chin Med, 1,9(4):244-247.
    引证文献
引用本文

彭毅,陈伟强,黄嘉文,赵华云.脉压指数联合动脉硬化指数对冠心病患者冠状动脉病变严重程度的预测价值[J].中国动脉硬化杂志,2023,31(1):63~69.

复制
分享
文章指标
  • 点击次数:805
  • 下载次数: 1261
历史
  • 收稿日期:2022-06-02
  • 最后修改日期:2022-08-17
  • 在线发布日期: 2022-12-26

您是本站第 4902199 访问者

邮编：421001 传真：0734-8160523

电话：0734-8160765 E-mail：dmzzbjb@163.net

中国动脉硬化杂志 ® 2025 网站版权所有