血尿酸水平在出血转化发生机制中的作用研究进展
作者:
作者单位:

(南华大学附属南华医院神经内科,湖南省衡阳市 421001)

作者简介:

陈尔汉,硕士研究生,研究方向为脑血管病的防治,E-mail:819456265@qq.com。通信作者汤永红,硕士,主任医师,教授,硕士研究生导师,研究方向为脑血管病的防治,E-mail:tyh6246@163.com。

基金项目:

湖南省科技创新重点工程项目(2020SK1012);南华大学一般指导项目(南华科发[2019]02)


Research progress on the role of serum uric acid level in the pathogenesis of hemorrhagic transformation
Author:
Affiliation:

Department of Neurology, Nanhua Hospital Affiliated to University of South China, Hengyang, Hunan 421001, China)

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    摘要:

    血尿酸在机体内具有抗氧化和促氧化的双重生理特性。出血转化是急性缺血性脑卒中常见的并发症,其发生严重影响患者的预后。出血转化的发生与氧化应激、病理性炎症反应、血脑屏障破坏及阿替普酶溶栓等密切相关。大量研究表明,血尿酸通过多种途径影响了出血转化的发生与发展。文章对近年相关研究进行综述,为出血转化的防治提供参考。

    Abstract:

    Serum uric acid plays dual role in physiological conditions. Hemorrhagic transformation(HT) is a common complication of acute ischemic stroke, which deteriorates the prognosis of ischemic stroke. The pathogenesis of hemorrhagic transformation is closely related to oxidative stress, inflammatory cascade, destruction of blood-brain barrier and alteplase thrombolysis. Many previous studies have shown that serum uric acid affects the occurrence and development of hemorrhagic transformation through a variety of ways. The aim of this article is to systematically review relevant research to improve the prognosis of hemorrhagic transformation.

    参考文献
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引用本文

陈尔汉,夏凤娟,程艳华,汤永红.血尿酸水平在出血转化发生机制中的作用研究进展[J].中国动脉硬化杂志,2022,30(11):930~934.

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  • 收稿日期:2022-03-30
  • 最后修改日期:2022-08-27
  • 在线发布日期: 2022-11-07