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丹参-川芎药对治疗心脑血管疾病的作用机制及临床研究
作者:
作者单位:

(1.天津中医药大学省部共建组分中药国家重点实验室,天津市 300193;2.天津国际生物医药联合研究院中药新药研发中心,天津市 300457;3.杜兰大学医学院临床神经科学研究中心神经外科系,纽约市 70118)

作者简介:

赵玉涵,硕士研究生,研究方向为心脑血管疾病,E-mail为1392109757@qq.com。通信作者朱彦,博士,教授,博士研究生导师,研究方向为心脑血管疾病现代中药的创制、技术升级和开发应用,天然组合药物的发现及作用机制解析,E-mail为yanzhu.harvard@icloud.com。

基金项目:

国家重点研发计划项目(2018YFC1704502)；国家自然科学基金资助项目(81873037)


Mechanism and clinical study of Danshen-Chuanxiong herbal pair in the treatment of cardiovascular and cerebrovascular diseases
Author:
  • ZHAO Yuhan 1,2

    ZHAO Yuhan

    State Key Laboratory of Component Traditional Chinese Medicine Jointly Established by the Province and the Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Joint Research Institute, Tianjin 300457, China
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  • XIAO Guangxu 1,2

    XIAO Guangxu

    State Key Laboratory of Component Traditional Chinese Medicine Jointly Established by the Province and the Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Joint Research Institute, Tianjin 300457, China
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  • FAN Siwen 1,2

    FAN Siwen

    State Key Laboratory of Component Traditional Chinese Medicine Jointly Established by the Province and the Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Joint Research Institute, Tianjin 300457, China
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  • WANG Xiaoying 3

    WANG Xiaoying

    Department of Neurosurgery, Center for Clinical Neuroscience Research, Tulane University School of Medicine, New York 70118, USA
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  • ZHU Yan 1,2

    ZHU Yan

    State Key Laboratory of Component Traditional Chinese Medicine Jointly Established by the Province and the Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Joint Research Institute, Tianjin 300457, China
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Affiliation:

1.State Key Laboratory of Component Traditional Chinese Medicine Jointly Established by the Province and the Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Joint Research Institute, Tianjin 300457, China;3.Department of Neurosurgery, Center for Clinical Neuroscience Research, Tulane University School of Medicine, New York 70118, USA)

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    摘要:

    药物配伍是中药复方的关键指导思想,也是中药现代化研究的重要内容。丹参与川芎在中医临床中广泛用于防治心脑血管疾病,如冠心病、心绞痛、脑卒中和动脉粥样硬化等。近期研究发现,丹参-川芎药对为活血化淤类复方中药中最常见的组合,能够发挥抗动脉粥样硬化、减轻血管内皮损伤、抗炎症反应、抗缺血再灌注损伤、抗血栓等药理作用。本文从物质基础、作用机制、临床应用等方面对丹参-川芎药对的研究进行了系统性阐述,为基于丹参-川芎药对组合现代中药的合理应用与有效开发提供了依据。

    Abstract:

    Drug compatibility is the key guiding ideology of traditional Chinese medicine compound prescriptions, and it is also an important content of the modernization research of traditional Chinese medicine. Danshen and Chuanxiong are widely used in traditional Chinese medicine clinic to prevent and treat cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, stroke and atherosclerosis, etc. Recent studies have found that Danshen-Chuanxiong herbal pair is the most common combination in traditional Chinese medicine for blood-activating and stasis-removing, which can exert pharmacological effects such as anti-atherosclerosis, alleviation of vascular endothelial injury, anti-inflammatory response, anti-ischemia/reperfusion injury, and anti-thrombosis. This paper systematically expounds the research on Danshen-Chuanxiong herbal pair from the aspects of material basis, mechanism of action, and clinical application, and provides a basis for the rational application and effective development of modern Chinese medicine based on the Danshen-Chuanxiong herbal pair.

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引用本文

赵玉涵,肖光旭,范斯文,王晓英,朱彦.丹参-川芎药对治疗心脑血管疾病的作用机制及临床研究[J].中国动脉硬化杂志,2022,30(6):461~469.

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  • 收稿日期:2021-09-29
  • 最后修改日期:2021-11-06
  • 在线发布日期: 2022-05-10

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