非编码RNA对心血管衰老调节的作用及进展
作者:
作者单位:

(1.哈尔滨医科大学附属第二医院心血管内科,;2.哈尔滨市心肌缺血教育部重点实验室,黑龙江省哈尔滨市 150001)

作者简介:

郑玉琪,硕士研究生,研究方向为动脉粥样硬化的分子机制,E-mail为zyq3970586@163.com。通信作者田进伟,博士,主任医师,博士研究生导师,研究方向为动脉粥样硬化的分子机制,E-mail为tianjinweidr2009@163.com。

基金项目:

国家重点研发计划项目(2016YFC1301304);霍英东青年教师基金项目(171032);黑龙江省应用技术研究与开发计划项目(GA20C007)


The role of non-coding RNA in the regulation of cardiovascular aging and its progress
Author:
Affiliation:

1.Department of Cardiovascular Medicine, The Second Affiliated Hospital of Harbin Medical University, ;2.Harbin Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin, Heilongjiang 150001, China)

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    摘要:

    衰老是心血管疾病的重要危险因素之一。随着世界老龄化进程加快,心血管衰老性疾病患者的发病率和死亡率也显著增加。非编码RNA为探索心血管衰老性疾病提供了新的分子视角,众多研究表明非编码RNA在心血管衰老过程中发挥重要作用。本文综述了非编码RNA对心血管衰老调节的作用及进展,以期为心血管衰老性疾病提供新的治疗策略。

    Abstract:

    Aging is one of the important risk factors of cardiovascular disease. With the rapid aging process in the world, the morbidity and mortality of patients with cardiovascular aging diseases have also increased significantly. Non-coding RNA provides a new molecular perspective for exploring cardiovascular aging diseases. Many studies have shown that non-coding RNA plays an important role in cardiovascular aging. The purpose of this review is to elucidate the role and progress of non-coding RNA in the regulation of cardiovascular aging, and to provide new therapeutic strategies for cardiovascular aging diseases.

    参考文献
    [1] ZHONG L, ZHEN M, SUN J, et al.Recent advances on the machine learning methods in predicting ncRNA-protein interactions.Mol Genet Genomics, 1,6(2):243-258.
    [2] PANNI S, LOVERING R C, PORRAS P, et al.Non-coding RNA regulatory networks.Biochim Biophys Acta Gene Regul Mech, 0,3(6):194417.
    [3] MESCHIARI C A, ERO O K, PAN H, et al.The impact of aging on cardiac extracellular matrix.Geroscience, 7,9(1):7-18.
    [4] PULAKAT L, CHEN H H.Pro-senescence and anti-senescence mechanisms of cardiovascular aging:cardiac microRNA regulation of longevity drug-induced autophagy.Front Pharmacol, 0,1:774.
    [5] ABDELGAWAD I Y, SADAK K T, LONE D W, et al.Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence.Pharmacol Ther, 1,1:107751.
    [6] OBAS V, VASAN R S.The aging heart.Clin Sci (Lond), 8,2(13):1367-1382.
    [7] PICCA A, MANKOWSKI R T, BURMAN J L, et al.Mitochondrial quality control mechanisms as molecular targets in cardiac ageing.Nat Rev Cardiol, 8,5(9):543-554.
    [8] UNGVARI Z, TARANTINI S, SOROND F, et al.Mechanisms of vascular aging,a geroscience perspective.J Am Coll Cardiol, 0,5(8):931-941.
    [9] NI Y Q, ZHAN J K, LIU Y S.Roles and mechanisms of MFG-E8 in vascular aging-related diseases.Ageing Res Rev, 0,4:101176.
    [10] 卿即娜, 陈红阳, 尹琳洁, 等.血管内皮细胞衰老与心血管疾病的相关性.中国动脉硬化杂志, 9,7(2):161-168.
    [11] UNGVARI Z, TARANTINI S, SOROND F, et al.Mechanisms of vascular aging, a geroscience perspective:JACC focus seminar.J Am Coll Cardiol, 0,5(8):931-941.
    [12] DU S, LING H, GUO Z, et al.Roles of exosomal miRNA in vascular aging.Pharmacol Res, 1,5:105278.
    [13] BATTISTONI A, MICHIELON A, MARINO G, et al.Vascular aging and central aortic blood pressure:from pathophysiology to treatment.High Blood Press Cardiovasc Prev, 0,7(4):299-308.
    [14] 韩爽, 陈宇, 张伟丽.长链非编码RNA的竞争性内源RNA调控模式在动脉粥样硬化中的研究进展.中国动脉硬化杂志, 1,9(3):185-192.
    [15] ZHANG X Z, LIU H, CHEN S R.Mechanisms of long non-coding RNAs in cancers and their dynamic regulations.Cancers (Basel), 0,2(5):1245.
    [16] ZHANG X, CHENG L, XU L, et al.The lncRNA, H19 mediates the protective effect of hypoxia postconditioning against hypoxia-reoxygenation injury to senescent cardiomyocytes by targeting microRNA-29b-3p.Shock, 9,2(2):249-256.
    [17] CHUN Y X, HUI Z D, BOND L W, et al.lncRNA ENSMUST00000134285 increases MAPK11 activity, regulating aging-related myocardial apoptosis.J Gerontol A Biol Sci Med Sci, 8,3(8):1010-1017.
    [18] TREMBINSKI D J, BINK D I, THEODOROU K, et al.Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction.Nat Commun, 0,1(1):2039.
    [19] BIAN W, JING X H, YANG Z, et al.Downregulation of lncRNA NORAD promotes ox-LDL-induced vascular endothelial cell injury and atherosclerosis.Aging (Albany NY), 0,2(7):6385-6400.
    [20] JY Z, CUI X J, ZHAN J K, et al.LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.Ann N Y Acad Sci, 0,4(1):61-72.
    [21] HAEMMIG S, YANG D, SUN X, et al.Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence.Sci Transl Med, 0,2(531):eaaw1868.
    [22] XIA W, CHEN H, XIE C, et al.Long-noncoding RNA MALAT1 sponges microRNA-92a-3p to inhibit doxorubicin-induced cardiac senescence by targeting ATG4a.Aging (Albany NY), 0,2(9):8241-8260.
    [23] XIE Z, XIA W, HOU M.Long intergenic non-coding RNA-p21 mediates cardiac senescence via the Wnt/β-catenin signaling pathway in doxorubicin-induced cardiotoxicity.Mol Med Rep, 8,7(2):2695-2704.
    [24] TAN P, GUO Y H, ZHAN J K, et al.LncRNA-ANRIL inhibits cell senescence of vascular smooth muscle cells by regulating miR-181a/Sirt1.Biochem Cell Biol, 9,7(5):571-580.
    [25] TIWARI A, MUKHERJEE B, DIXIT M.MicroRNA key to angiogenesis regulation:miRNA biology and therapy.Curr Cancer Drug Targets, 8,8(3):266-277.
    [26] SCHERM M G, DANIEL C.miRNA regulation of T cells in islet autoimmunity and type 1 diabetes.Curr Diab Rep, 0,0(9):41.
    [27] SOBOLEWSKI C, CALO N, PORTIUS D, et al.MicroRNAs in fatty liver disease.Semin Liver Dis, 5,5(1):12-25.
    [28] GJORGJIEVA M, SOBOLEWSKI C, DOLICKA D, et al.miRNAs and NAFLD:from pathophysiology to therapy.Gut, 9,8(11):2065-2079.
    [29] CORREIA D M, GJORGJIEVA M, DOLICKA D, et al.Deciphering miRNAs' action through miRNA editing.Int J Mol Sci, 9,0(24):6249.
    [30] KINSER H, PINCUS Z.MicroRNAs as modulators of longevity and the aging process.Hum Genet, 0,9(3):291-308.
    [31] LIN R, RAHTU-KORPELA L, MAGGA J, et al.miR-1468-3p promotes aging-related cardiac fibrosis.Mol Ther Nucleic Acids, 0,0:589-605.
    [32] BEI Y, WU X, CRETOIU D, et al.miR-21 suppression prevents cardiac alterations induced by D-galactose and doxorubicin.J Mol Cell Cardiol, 8,5:130-141.
    [33] LYU G, GUAN Y, ZHANG C, et al.TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging.Nat Commun, 8,9(1):2560.
    [34] DE YBENES V G, BRIONES A M, MARTOS-FOLGADO I, et al.Aging-associated miR-217 aggravates atherosclerosis and promotes cardiovascular dysfunction.Arterioscler Thromb Vasc Biol, 0,0(10):2408-2424.
    [35] DHAHRI W, DUSSAULT S, LGAR , et al.Reduced expression of microRNA-130a promotes endothelial cell senescence and age-dependent impairment of neovascularization.Aging (Albany NY), 0,2(11):10180-10193.
    [36] CHEN Y L, SHEU J J, SUN C K, et al.MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis.Mol Med, 0,6(1):46.
    [37] DONG F, DONG S, LIANG Y, et al.miR-20b inhibits the senescence of human umbilical vein endothelial cells through regulating the Wnt/β-catenin pathway via the TXNIP/NLRP3 axis.Int J Mol Med, 0,5(3):847-857.
    [38] ZHANG Y, LIANG Q, ZHANG YAD-DEPARTMENT OF CARDIOLOGY T F, et al.Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/SDC1 axis.Am J Transl Res, 0,2(9):5205-5220.
    [39] KHOR E S, WONG P F.Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves microRNA-107.Int J Biochem Cell Biol, 8,1:64-73.
    [40] LIU H, WU H Y, WANG W Y, et al.Regulation of miR-92a on vascular endothelial aging via mediating Nrf2-KEAP1-ARE signal pathway.Eur Rev Med Pharmacol Sci, 7,1(11):2734-2742.
    [41] CHAICHIAN S, SHAFABAKHSH R, MIRHASHEMI S M, et al.Circular RNAs:a novel biomarker for cervical cancer.J Cell Physiol, 0,5(2):718-724.
    [42] LI R, JIANG J, SHI H, et al.CircRNA:a rising star in gastric cancer.Cell Mol Life Sci, 0,7(9):1661-1680.
    [43] PREUBER C, HUNG L H, SCHNEIDER T, et al.Selective release of circRNAs in platelet-derived extracellular vesicles.J Extracell Vesicles, 8,7(1):1424473.
    [44] CONN V M, HUGOUVIEUX V, NAYAK A, et al.A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation.Nat Plants, 7,3:17053.
    [45] LIU Z, YU Y, HUANG Z, et al.CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression.Cell Death Dis, 9,0(12):900.
    [46] WANG Z, LEI X.Matrix factorization with neural network for predicting circRNA-RBP interactions.BMC Bioinformatics, 0,1(1):229.
    [47] SHI Y, JIA X, XU J.The new function of circRNA:translation.Clin Transl Oncol, 0,2(12):2162-2169.
    [48] DU W W, YANG W, CHEN Y, et al.Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses.Eur Heart J, 7,8(18):1402-1412.
    [49] WANG S, ZHAN J, LIN X, et al.CircRNA-0077930 from hyperglycaemia-stimulated vascular endothelial cell exosomes regulates senescence in vascular smooth muscle cells.Cell Biochem Funct, 0,8(8):1056-1068.
    [50] WEI H, CAO C, WEI X, et al.Circular RNA circVEGFC accelerates high glucose-induced vascular endothelial cells apoptosis through miR-338-3p/HIF-1α/VEGFA axis.Aging (Albany NY), 0,2(14):14365-14375.
    [51] GAO W Q, HU X M, ZHANG Q, et al.Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis.Aging (Albany NY), 0,3(3):3588-3604.
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郑玉琪,朴明慧,田进伟.非编码RNA对心血管衰老调节的作用及进展[J].中国动脉硬化杂志,2022,30(2):111~116.

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  • 收稿日期:2021-04-01
  • 最后修改日期:2021-10-04
  • 在线发布日期: 2022-01-07