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线粒体相关内质网膜:心血管疾病治疗的新靶点
作者:
作者单位:

(哈尔滨医科大学,黑龙江省哈尔滨市 150081)

作者简介:

董博文,硕士研究生,主要研究方向为心血管疾病防治机制,E-mail为726604784@qq.com。杨力明,教授,博士研究生导师,研究方向为生物医学工程介导的心血管疾病防治。

基金项目:

国家自然科学基金资助项目(91939104、82070465和82170469)；黑龙江省自然科学基金杰出青年项目(JQ2021H001)；心血管疾病国家重点实验室开放课题资助项目(2019kf-02)；心肌缺血教育部重点实验室开放课题资助项目(KF201908)；黑龙江省卫生健康委面上项目(2020-075)


Mitochondria-associated ER membranes:a new target for the treatment of cardiovascular diseases
Author:
Affiliation:

Harbin Medical University, Harbin, Heilongjiang 150081, China)

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    摘要:

    线粒体相关内质网膜是指内质网和线粒体之间高度动态的紧密连接部分,参与维持内质网和线粒体的正常功能,与细胞脂质代谢、钙稳态、线粒体动力学、自噬和凋亡、内质网应激和炎症等密切相关。研究显示线粒体相关内质网膜功能异常或者数量和结构改变参与心血管疾病的发生发展。本文总结了线粒体相关内质网膜的功能,阐述了其在心血管疾病中的作用及可能机制,为线粒体相关内质网膜成为心血管疾病治疗的新靶点提供理论参考。

    Abstract:

    The highly dynamic tight junctions between the endoplasmic reticulum and mitochondria are known as mitochondria-associated ER membranes. These domains are essential for basic biological processes, including lipid metabolism, calcium homeostasis, mitochondrial dynamics, autophagy and apoptosis, endoplasmic reticulum stress and inflammation. Many studies have proved the abnormal amount, structure or function of mitochondria-associated ER membranes are related to the occurrence and development of cardiovascular diseases. This paper summarized the functions of mitochondria-associated ER membranes and its roles and possible mechanism in cardiovascular diseases, and provided theoretical references for mitochondria-associated ER membranes to become new targets for cardiovascular therapy.

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董博文,王子同,于雪,李弘,杨力明.线粒体相关内质网膜:心血管疾病治疗的新靶点[J].中国动脉硬化杂志,2021,29(12):1013~1020.

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  • 收稿日期:2021-07-05
  • 最后修改日期:2021-08-14
  • 在线发布日期: 2021-11-24

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