急性心肌梗死患者C反应蛋白与白蛋白比值与冠状动脉狭窄程度的相关性
作者:
作者单位:

(1.新疆维吾尔自治区人民医院急救中心,;2.新疆医科大学,新疆乌鲁木齐市 830000)

作者简介:

吐尔孙阿依·依斯米提拉,硕士,住院医师,主要从事冠状动脉血栓形成机制研究,E-mail为AliTur@qq.com。通信作者穆叶赛·尼加提,博士后,主任医师,主要从事急诊重症、心血管重症、冠心病介入治疗等临床和基础研究,E-mail为muyassar11@aliyun.com。

基金项目:

国家自然科学基金项目(81760068)


Relationship between C-reactive protein to albumin ratio and the degree of coronary artery disease in patients with acute myocardial infarction
Author:
Affiliation:

1.Emergency Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang 830000, China;2.Medical University of Xinjiang, Urumqi, Xinjiang 830000, China)

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    摘要:

    目的 探讨新定义的C反应蛋白(CRP)与白蛋白比值(CAR)与其他炎症标志物[如中性粒细胞与淋巴细胞比率(NLR)、血小板与淋巴细胞比率(PLR)、单核细胞与淋巴细胞比率(MLR)]相比在确定冠状动脉狭窄程度方面的预测价值。方法 纳入2018年1月1日—2020年1月1日在新疆维吾尔自治区人民医院心血管内科住院并行冠状动脉造影检查的急性心肌梗死患者(AMI组,n=203例)和非AMI的冠心病患者(非AMI组,n=103例),再根据Syntax评分将AMI组分为两组:低Syntax评分组(Syntax评分≤22分,n=124例)和高Syntax评分组(Syntax评分≥23分,n=79例)。测定CAR、NLR、PLR和MLR,比较各组CAR、NLR、PLR和MLR的水平差异,评估CAR和NLR、PLR、MLR水平与冠状动脉狭窄程度的关系。结果 AMI组患者的CAR、NLR、PLR、MLR水平明显高于非AMI组(P<0.001)。相关性分析发现,CAR与Syntax评分显著相关(r=0.634,P<0.001),而NLR、PLR、MLR与Syntax呈低相关(r=0.304,P<0.001;r=0.463,P<0.001;r=0.344,P<0.001)。Logistic回归分析显示,CAR水平是高Syntax评分的唯一独立危险因素(OR=1.08,95%CI为1.004~1.161,P=0.038)。结论 炎症标志物CAR水平与冠状动脉狭窄程度存在相关性,可作为预测AMI患者冠状动脉狭窄程度的可靠标志物。

    Abstract:

    Aim To explore the predictive value of the newly defined C-reactive protein (CRP) to albumin ratio (CAR) in determining the degree of coronary artery stenosis compared with other inflammatory markers, such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR). Methods Patients with acute myocardial infarction (n=203) and patients with non-AMI coronary heart disease (n=103) hospitalized in the Department of Cardiology of the People's Hospital of Xinjiang Uygur Autonomous Region from January 1,8 to January 1,0 were included. According to the syntax score, AMI group was divided into two groups:low Syntax score group (Syntax score≤22 points, n=124) and high Syntax score group (Syntax score≥23, n=79). CAR, NLR, PLR and MLR were measured, the levels of CAR, NLR, PLR and MLR in each group were compared, and the relationship between the levels of CAR, NLR, PLR and MLR and the degree of coronary artery stenosis was evaluated.. Results The levels of CAR, NLR, PLR and MLR in AMI group were significantly higher than those in non-AMI group (P<0.001). Correlation analysis showed that CAR was significantly correlated with Syntax score (r=0.634, P<0.001), while NLR, PLR and MLR were low correlated with Syntax (r=0.304, P<0.001; r=0.463, P<0.001; r=0.344, P<0.001). Logistic regression analysis showed that CAR level was the only independent risk factor for high Syntax score (OR=1.8,5%CI:1.004~1.161, P=0.038). Conclusion The level of inflammatory marker CAR is correlated with the degree of coronary artery stenosis, which can be used as a reliable marker to predict the degree of coronary artery stenosis in AMI patients.

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吐尔孙阿依·依斯米提拉,阿里米江·阿布里米提,穆叶赛·尼加提.急性心肌梗死患者C反应蛋白与白蛋白比值与冠状动脉狭窄程度的相关性[J].中国动脉硬化杂志,2021,29(10):869~874.

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  • 收稿日期:2020-08-12
  • 最后修改日期:2020-10-17
  • 在线发布日期: 2021-10-13