H型高血压患者颈动脉粥样硬化相关危险因素分析
作者:
作者单位:

(1.无锡市第三人民医院心内科,江苏省无锡市 214000;2.苏州大学附属第一医院心内科,江苏省苏州市 215000 )

作者简介:

尚晖,硕士研究生,住院医师, 研究方向为高血压病,E-mail为shanghuismmu@163.com。


Risk factors of carotid atheroscleosis in patients with H-type hypertension
Author:
Affiliation:

1.Department of Cardiology, the Third People's Hospital of Wuxi, Wuxi, Jiangsu 214000, China;2.Department of Cardiology, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu 215000, China)

  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • | |
    摘要:

    目的 探讨H型高血压患者发生颈动脉粥样硬化的相关危险因素。方法 纳入原发性高血压患者240例,根据血浆同型半胱氨酸(Hcy)水平是否≥10 μmol/L,分为H型高血压组(H组)118例和单纯高血压组(单纯组)122例,比较两组患者一般情况、生化指标、颈动脉血管壁内膜-中膜厚度(IMT)和颈动脉斑块数量。采用多因素Logistic回归分析H组患者发生颈动脉粥样硬化的相关危险因素。结果 H型高血压患者在性别构成、冠心病病史、脑卒中病史、收缩压、脉压、Hcy、低密度脂蛋白(LDLC)、尿素氮(BUN)和肌酐(Cr)、尿酸(UA)、劲动脉斑块形成、斑块数、IMT、斑块数≥3个、50%狭窄的检出率等方面均高于单纯组(P<0.05)。Logistic多元回归分析显示,H型高血压患者颈动脉IMT与高龄、吸烟和高LDLC显著相关(P<0.05),危险度分别为1.282(95%CI 1.133~1.451)、6.663(95%CI 1.200~20.669)和4.301(95%CI 1.199~15.434);斑块形成与高龄、男性和超重显著相关(P<0.05),危险度分别为1.150(95%CI 1.069~1.238)、3.496(95%CI 1.353~9.033)和1.244(95%CI 1.014~1.526)。结论 H型高血压患者颈动脉IMT与高龄、吸烟和高LDLC显著相关;斑块形成则与高龄、男性和超重显著相关。

    Abstract:

    Aim To investigate the carotid atherosclerosis risk factors of H-type hypertension. Methods A total of 240 hospitalized patients with primary hypertension from january 2017 to january 2018 were selected. According to the plasma homocysteine(Hcy) level, participators were divided into H-type hypertenion group(H-group, plasma Hcy>10 μmol/L)with 118 cases and simple group(plasma Hcy≤10 μmol/L) with 122 cases. Patients' general information, biochemical index, carotid intima-media thickness(IMT), carotid atherosclerotic plaques and the condition of carotid stenosis, were compared between the two groups. Multivariate Logistic regression was used to analyze the risk factors of carotid atherosclerosis in H-group patients. Results Male composition, coronary heart disease history, stroke history, mean systolic blood pressure , pulse pressure, plasma Hcy, low density liporotein cholesterol(LDLC), urea nitrogen(BUN), creatinine(Cr) and uric acid(UA) levels, the detection rate of the carotid IMT, plaque formation, IMT, the plaque number≥3, carotid stenosis >50% in H group were significantly different from simple group(P<0.05). Multivariate Logistic regression analysis demonstrated that aged, smoking history, high LDL were significantly associated with carotid IMT in H-type hypertension patients, with OR values 1.282(95%CI 1.133~1.451), 663(95%CI 1.200~ 20.669), 4.301(95%CI 1.199~15.434) respectively. Moreover, aged, overweight, high LDL with OR values 1.150(95% CI 1.069~1.238), 3.496(95%CI 1.353~9.033), 1.244(95%CI 1.014~1.526)were significantly associated with plaque formation. Conclusions Aged, smoking history, high LDL were significantly associated with carotid IMT of H-type hypertension patients. Aged, overweight, high LDL had significant effect on the progression of plaque formation.

    参考文献
    [1] Mc Cully KS.Vascular pathology of homocysteinemia:implications for the pathogenesis of artcrioscicrosis .Am J Pathol, 9,6(1):111-128.
    [2] Refsum H, Ueland PM, Nygard O, et al.Homocysteine and cardiovascular disease.Annu Rev Med, 8,9: 31-62.
    [3] 胡大一, 徐希平.有效控制“H型”高血压——预防卒中的新思路.中华内科杂志, 8,7 (12):976-977.
    [4] 李建平, 霍勇, 刘平, 等.马来酸依那普利叶酸片降压降同型半胱氨酸的疗效和安全性.北京大学学报(医学版), 7,9(6):614-618.
    [5] 刘力生.中国高血压防治指南2010.中华高血压杂志, 1,9(8):701-743.
    [6] 赵雪, 辛建丽, 孙海玉.不同性别高血压患者血浆同型半胱氨酸水平的差别.中国实用神经疾病杂志, 6,9(4):68-69.
    [7] González-Gross M, Benser J, Breidenassel C, et al.Gender and age influence blood folate, vitamin B12, vitamin B6, and homocysteine levels in European adolescents:the Helena Study.Nutr Res., 2,2(11):817-826.
    [8] 冯强.叶酸及维生素B(12)与H型高血压的相关性研究.国际检验医学杂志, 2,3(14):1746-1747.
    [9] 张铁梅, 樊昕, 徐秀英.血Hcy同型半胱氨酸水平对原发性高血压患者血压变异性和动脉硬化影响的研究.中国医药导刊, 5,7(5):445-446,448.
    [10] The homocysteine studies collaboration.Homocysteine and risk of ischemic heart disease and stroke; a metaanalysis.JAMA, 2,8(16):2015-2022.
    [11] Towfighi A, Markovic D, Ovbiagele B.Pronounced association of elevated serum homocysteine with stroke in subgroups of individuals:a nationwide study.J Neurol Sci, 0,8(1-2):153-157.
    [12] OK, Lynn EG, Chung YH, et al.Homocysteine stimulates the production and secretion of cholesterol in hepatic cells.Biochimica Et Biophysica Acta, 8,3(2-3):317.
    [13] 郝清清, 周子逸, 翁浩宇, 等.健康体检人群同型半胱氨酸与血脂相关性分析.中国实用内科杂志, 8,8(1):47-51.
    [14] 石晶晶, 王欢, 胡元会, 等.高血压病人血清同型半胱氨酸与肾功能指标的相关性分析.中西医结合心脑血管病杂志, 8,6(2):140-142.
    [15] 战晓丽, 金惠敏.同型半胱氨酸与慢性肾脏病的研究进展.中国中西医结合肾病杂志, 8,9(4):357-359.
    [16] Schalinske KL, Smazal AL.Homocysteine imbalance:a pathological metabolic marker .Adv Nutr, 2,3(2):755-762.
    [17] Yi F, Li PL.Mechanisms of homocysteine-induced glomerular injury and sclerosis.Am J Nephrol, 8,8(2):254-264.
    [18] Long Y, Nie J.Homocysteine in renal injury .Kidney Dis(Basel), 6,2(2):80-87.
    [19] Hwang SY, Woo CW, Auyeung KK, et al.Homocysteine stimulates monocyte chemoattractant protein-1expression in the kidney via nuclear factor-kappa B activation..Am J Physiol Renal Physiol, 8,4(1):F236.
    [20] Qin X, Li Y, He M, et al.Folic acid therapy reduces serum uric acid in hypertensive patients:a substudy of he China Stroke Primary Prevention Trial (CSPPT) .Am J Clin Nutr, 7,5(4):882.
    [21] 张涛, 吕纯芳, 刘琨, 等.高血压患者血浆同型半胱氨酸与年龄、性别、尿酸及血脂的相关性分析.实用预防医学, 3,0(7):786-788.
    [22] Bots ML, Sutton-Tyrrell K.Lessons from the past and promises for the future for carotid inti-mamedia thickness.J Am Coll Cardiol, 2,0(17):1599-1604.
    [23] The Homocysteine Studies Collaboration.Homocysteine and risk of ischemic heart disease a- nd stroke:a meta-analysis .JAMA, 2,8(16):2015-2022.
    [24] Sen U, Mishra PK, Tyagi N, et al.Homocysteine to hydrogen sulfide or hypertension .Cell Biochem Biophys, 0,7(2-3):49-58.
    [25] Tayama J, Munakata M, Yoshinaga K, et al.Higher plasma Homocysteine concentration is associated with more advanced systemic arterial stiffness and greater blood pressure response to stress in hypertensive patients.Hypertension Res, 6,5(6):403-409.
    [26] 彭红艳.同型半胱氨酸致血管内皮细胞骨架肌动蛋白损伤的实验研究.广州:暨南大学, 2008:24-27.
    [27] 李春亚, 任颜颜, 范永省.脉压差与老年高血压病患者动脉硬化形成的关系研究.医药论坛杂志, 1,2(1):36-37.
    [28] 杨欣, 丁毅.颈动脉粥样硬化危险因素及意义的研究进展.医学综述, 5,1(2):239-241.
    [29] 王广娟, 赵颖馨, 张慧, 等.吸烟及高同型半胱氨酸血症对冠心病的交互作用.实用医学杂志, 8,4(3):468-471.
    [30] 庞阳.吸烟与冠状动脉粥样硬化程度的相关性研究.太原:山西医科大学, 2018:17-20.
    [31] 张洁琼, 任力杰, 韩漫夫, 等.吸烟与颈动脉斑块形成及其性质的相关性研究.中国医药导报, 4,1(30):26-29.
    [32] 商鲁翔.山东省中老年人颈动脉斑块的危险因素及聚集性分析.济南: 济南大学, 2017:29-31.
    [33] 张丽娟.肥胖儿童血浆同型半胱氨酸的变化及其相关因素的分析.大连: 大连医科大学, 2010:20-23.
    [34] 钟华荣, 吕安康, 沈卫峰.从分子机制探讨肥胖致动脉粥样硬化.国际心血管病杂志, 7,4(5):327-330.
    [35] 诸骏仁, 高润霖, 赵水平, 等.中国成人血脂异常防治指南(2016年修订版).中国循环杂志, 6,1(10):937-953.
    [36] 中国成人血脂异常防治指南.中华心血管病杂志, 7,5(5):390-419.
    [37] 刘俊田.动脉粥样硬化发病的炎症机制的研究进展.西安交通大学学报(医学版), 5,6(2):141-152.
    引证文献
引用本文

尚晖,李勋. H型高血压患者颈动脉粥样硬化相关危险因素分析[J].中国动脉硬化杂志,2019,27(11):969~974, 984.

复制
分享
文章指标
  • 点击次数:687
  • 下载次数: 734
历史
  • 收稿日期:2019-03-08
  • 最后修改日期:2019-05-13
  • 在线发布日期: 2019-12-18