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血清中肝素结合表皮生长因子、磷酸二酯酶4D的水平与急性冠状动脉综合征的关系
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(郑州大学附属郑州中心医院1.转化医学中心,;2.心血管内科四病区,河南省郑州市 450007)

作者简介:

韩鹏黎,硕士,主管药师,研究方向为药理学,E-mail为hanpengli2013@163.com。


The relationship between the levels of HB-EGF, PDE4D in serum and acute coronary syndrome
Author:
Affiliation:

1.Translational Medicine Center, ;2.4# Department of Cardiology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China)

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    摘要:

    目的 探讨血清中肝素结合表皮生长因子(HB-EGF)、磷酸二酯酶4D(PDE4D)的水平与急性冠状动脉综合征的关系。 方法 采用双抗体夹心ABC-ELISA法检测50例急性冠状动脉综合征患者(ACS 组)及100例正常对照者(对照组)的HB-EGF蛋白及PDE4D蛋白的血清水平,运用Logistic回归分析评估它们与ACS的关系。 结果 校正高血压、吸烟、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC)、体质指数(BMI)等单因素分析有意义的因素后,发现HB-EGF蛋白水平与是否罹患ACS有关[OR=4.114,95%CI为(1.782,9.498),P=0.001]；PDE4D蛋白水平也与是否罹患ACS有关[OR=5.049,95%CI为(1.764,14.448),P=0.003]。 结论 血清中HB-EGF、PDE4D水平与是否罹患急性冠状动脉综合征有关,HB-EGF、PDE4D水平高者患急性冠状动脉综合征的风险高。

    Abstract:

    Aim To evaluate the relationship between the levels of heparin binding epidermal growth factor(HB-EGF), phosphodiesterase 4D (PDE4D) in serum and acute coronary syndrome(ACS). Methods The protein levels of HB-EGF, PDE4D were measured in serum of 50 patients with ACS (ACS group) and 100 cases normal control (normal control group) by double antibodies sandwich ABC-ELISA method. The relationship between the protein levels and ACS was evaluated by logistic regression analysis. Results After correcting for meaningful factors such as high blood pressure, smoking, TG, TC, LDLC, HDLC and BMI by single factor analysis, it found that the protein level of HB-EGF was associated with whether or not suffering from ACS (OR=4.4,5%CI was 1.2,9.498, P=0.001). The protein level of PDE4D was associated with whether or not suffering from ACS, too (OR=5.9,5%CI was 1.4,4.448, P=0.003). Conclusion The protein levels of HB-EGF, PDE4D in serum was associated with whether or not suffering from ACS. Cases with high protein levels of HB-EGF, PDE4D were at high risk of ACS.

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韩鹏黎,程晓丹,刘建华,刘新叶,池豪,曹巍,杨东伟.血清中肝素结合表皮生长因子、磷酸二酯酶4D的水平与急性冠状动脉综合征的关系[J].中国动脉硬化杂志,2017,25(11):1156~1158.

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  • 收稿日期:2016-12-05
  • 最后修改日期:2017-09-29
  • 在线发布日期: 2017-11-28

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