药物洗脱支架引起的去内皮化与支架内血栓形成机制的研究新进展
作者:
作者单位:

(中国中医科学院西苑医院心血管病研究中心, 北京市 100091)

作者简介:

王欣,住院医师,研究方向为冠心病的介入治疗,E-mail为coolwang1979@163.com。

基金项目:

国家自然科学基金资助项目(81473530);中国中医科学院西苑医院课题项目[XYKY-MP(2013)-(30)];中国中医科学院基本科研业务费自主选题项目(ZZ0708106)


New progress in the study of DES-induced deendothelialization and stent thrombosis
Author:
Affiliation:

Cardiovascular Disease Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China)

  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
    摘要:

    药物洗脱支架(DES)因其显著的低支架再狭窄(ISR)发生率,在动脉粥样硬化性疾病中广泛应用。但是,大量研究发现,置入DES的患者发生支架内血栓形成的风险呈上升趋势。相关研究表明,支架内血栓形成的发生与支架血管内皮损伤紧密相连。损伤的内皮层可引起血小板黏附聚集、支架梁异位或支架内新生动脉粥样硬化形成。因此,本文就DES引起的内皮损伤和支架内血栓形成的具体相关机制以及目前研究的生物可降解支架对防御支架内血栓形成的作用做一简要概述。

    Abstract:

    Drug eluting stents (DES) have dramatically decreased the rate of in-stent restenosis, which are widely used in patients with atherosclerosis. However, as research continues, increasing evidences have demonstrated that the risk of DES-related stent thrombosis (ST) has tended to increase, which is closely associated with delayed endothelium coverage. Impaired endothelium could induce platelet adhesion and aggregation, incomplete stent apposition, or neoatherosclerosis development. Thus, we will discuss the detailed mechanisms for the DES-related deendothelialization and ST, and the effects of biodegradable stents on vascular endothelium.

    参考文献
    [1] Katsanos K, Kitrou P, Spiliopoulos S, et al.Comparative effectiveness of plain balloon angioplasty, bare metal stents, drug-coated balloons, and drug-eluting stents for the treatment of infrapopliteal artery disease:Systematic review and Bayesian network meta-analysis of randomized controlled trials.J Endovasc Ther, 6,3(6):851-863.
    [2] Wexberg P, Jordanova N, Strehblow C, et al.Time course of prothrombotic and proinflammatory substance release after intracoronary stent implantation.Thromb Haemost, 8,9(4):739-748.
    [3] Habib A, Karmali V, Polavarapu R, et al.Sirolimus-FKBP12.6 impairs endothelial barrier function through protein kinase C-α activation and disruption of the p120-vascular endothelial cadherin interaction.Arterioscler Thromb Vasc Biol, 3,3(10):2 425-431.
    [4] Lüscher TF, Steffel J, Eberli FR, et al.Drug-eluting stent and coronary thrombosis:biological mechanisms and clinical implications.Circulation, 7,5(8):1 051-058.
    [5] Ozaki Y, Okumura M, Ismail TF, et al.The fate of incomplete stent apposition with drug-eluting stents:an optical coherence tomography-based natural history study.Eur Heart J, 0,1(12):1 470-476.
    [6] Brener SJ, Prasad AJ, Khan Z, et al.The relationship between late lumen loss and restenosis among various drug-eluting stents:a systematic review and meta-regression analysis of randomized clinical trials.Atherosclerosis, 1,4(1):158-162.
    [7] Feres F, Costa JR, Abizaid A.Very late thrombosis after drug-eluting stents.Catheter Cardiovasc Interv, 6,8(1):83-88.
    [8] Timmers L, Belkacemi A, Agostoni P, et al.Optical coherence tomography imaging of acute stent thrombosis after Stentys stent implantation.J Am Coll Cardiol, 3,1(17):e165.
    [9] Elmariah S, Jang IK.Acute stent thrombosis:technical complication or inadequate antithrombotic therapy? An optical coherence tomography study.JACC Cardiovasc Interv, 2,5(2):e3-4.
    [10] Geisler T, Zürn C, Simonenko R, et al.Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions.Eur Heart J, 0,1(1):59-66.
    [11] Moore C, Tymvios C, Emerson M.Functional regulation of vascular and platelet activity during thrombosis by nitric oxide and endothelial nitric oxide synthase.Thromb Haemost, 0,4(2):342-349.
    [12] Finn AV, Joner M, Nakazawa G, et al.Pathological correlates of late drug-eluting stent thrombosis:strut coverage as a marker of endothelialization.Circulation, 7,5(18):2 435-441.
    [13] Juni RP, Duckers HJ, Vanhoutte PM, et al.Oxidative stress and pathological changes after coronary artery interventions.J Am Coll Cardiol, 3,1(14):1 471-481.
    [14] Li Z, Delaney MK, O'Brien KA, et al.Signaling during platelet adhesion and activation.Arterioscler Thromb Vasc Biol, 0,0(12):2 341-349.
    [15] Palabrica T, Lobb R, Furie BC, et al.Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets.Nature, 2,9(6398):848-851.
    [16] Krtz F, Sohn HY, Pohl U.Reactive oxygen species:players in the platelet game.Arterioscler Thromb Vasc Biol, 4,4(11):1 988-996.
    [17] Ozturk C, Balta S, Demirkol S, et al.Increased platelet indices in acute stent thrombosis.Angiology, 4,5(8):744.
    [18] Attizzani GF, Capodanno D, Ohno Y, et al.Mechanisms, pathophysiology, and clinical aspects of incomplete stent apposition.J Am Coll Cardiol, 4,3(14):1 355-367.
    [19] Parodi G, La Manna A, Di VL, et al.Stent-related defects in patients presenting with stent thrombosis:differences at optical coherence tomography between subacute and late/very late thrombosis in the mechanism of stent thrombosis (MOST) study.EuroIntervention, 3,9(8):936-944.
    [20] Foin N, Gutiérrez-Chico JL, Nakatani S, et al.Incomplete stent apposition causes high shear flow disturbances and delay in neointimal coverage as a function of strut to wall detachment distance:implications for the management of incomplete stent apposition.Circ Cardiovasc Interv, 4,7(2):180-189.
    [21] Siqueira DA, Abizaid AA, Costa JR, et al.Late incomplete apposition after drug-eluting stent implantation:incidence and potential for adverse clinical outcomes.Eur Heart J, 7,8(11):1 304-309.
    [22] Cook S, Ladich E, Nakazawa G, et al.Correlation of intravascular ultrasound findings with histopathological analysis of thrombus aspirates in patients with very late drug-eluting stent thrombosis.Circulation, 9,0(5):391-399.
    [23] Park SJ, Kang SJ, Virmani R, et al.In-stent neoatherosclerosis:a final common pathway of late stent failure.J Am Coll Cardiol, 2,9(23):2 051-057.
    [24] Nakazawa G, Otsuka F, Nakano M, et al.The pathology of neoatherosclerosis in human coronary implants bare-metal and drug-eluting stents.J Am Coll Cardiol, 1,7(11):1 314-322.
    [25] Imai M, Kadota K, Goto T, et al戮慉扮汣敩?灥潮汣祥洬攠牲?捳潫愠瑦敡摣??敲癳攬爠潡汮楤洠畣獬?敮汩畣瑡楬渠杳?捱潵牥潬湡慥爠祯?猠瑡敮湧瑩?瑧桲敡??噩佣?噰?????剴慥湮摴漠浣楯穮整摲?味牴椠慳汴??楮物据??慡牦摴楥潲瘠慳獩捲??湩瑭敵牳瘭?????????整づの??????扡牮????孯??嵃?偲慣汵浬敡牴楩湯楮?吠???椨漲渱搩椺?娠漳挸挲愭椳?????敲氾氊愊?剛???攠瑈?慧汯??氬椠湕楥捤慡氠?漬甠瑏捹潡浢敵猠?眬椠瑥桴?扡楬漮慁扴獨潥牲扯慳扣汬敥?灯潴汩祣洠敡牮??癴敨牲獯畭獢?摧略牮慩扣氠敮?灯潩汮祴浩敭牡?扦慯獲敭摥?搠牯當来?攠汳畩瑲楯湬杩?慵湳搠?扲慵牧攭?浬敵瑴慩汮?猠瑳整湥瑮獴?敡癮椠摡敮湧捩敯?晣牯潰浩?愠?捴潵浤灹爮敊桁敃湃猠楃癡敲?湩敯瑶睡潳牣欠?浭敡瑧慩?慧測愠氹礬猲椨猵????洶??漲水氮??慲爾搊椊漊汛??????????????????扡牮????扊牆? Alviar CL, et al.Anti-CD34 antibodies immobilized on the surface of sirolimus-eluting stents enhance stent endothelialization.JACC Cardiovasc Interv, 0,3(1):68-75.
    [28] Duarte JH.Coronary artery disease:durable-polymer drug-eluting stents might not lead to very late stent thrombosis.Nat Rev Cardiol, 5,2(1):3.
    [29] Kaiser C, Galatius S, Jeger R, et al.Long-term efficacy and safety of biodegradable-polymer biolimus-eluting stents:main results of the Basel Stent Kosten-Effektivitts Trial-PROspective Validation Examination II (BASKET-PROVE II), a randomized, controlled noninferiority 2-year outcome trial.Circulation, 5,1(1):74-81.
    [30] Kang SJ, Lee CW, Song H, et al.OCT analysis in patients with very late stent thrombosis.JACC Cardiovasc Imaging, 3,6(6):695-703.
    [31] Kronstein R, Seebach J, Grossklaus S, et al.Caveolin-1 opens endothelial cell junctions by targeting catenins.Cardiovasc Res, 2,3(1):130-140.
    [32] Simionescu M.Implications of early structural-functional changes in the endothelium for vascular disease.Arterioscler Thromb Vasc Biol, 7,7(2):266-274.
    [33] Hirahashi J, Hishikawa K, Kaname S, et al.Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury.Circulation, 9,0(13):1 255-265.
    [34] Shantsila E, Kamphuisen PW, Lip GY.Circulating microparticles in cardiovascular disease:implications for atherogenesis and atherothrombosis.J Thromb Haemost, 0,8(11):2 358-368.
    [35] Angelillo-Scherrer A.Leukocyte-derived microparticles in vascular homeostasis.Circ Res, 2,0(2):356-369.
    [36] Kereiakes DJ, Meredith IT, Windecker S, et al.Efficacy and safety of a novel bioabsor
    相似文献
    引证文献
引用本文

王欣,崔源源,赵福海.药物洗脱支架引起的去内皮化与支架内血栓形成机制的研究新进展[J].中国动脉硬化杂志,2017,25(4):417~421.

复制
分享
文章指标
  • 点击次数:1012
  • 下载次数: 1233
历史
  • 收稿日期:2016-05-09
  • 最后修改日期:2016-11-05
  • 在线发布日期: 2017-05-18