活化T细胞核因子c1检测联合血管内超声在冠心病风险评价中的作用
作者:
作者单位:

(江苏大学附属医院心内科, 江苏省镇江市 2120001)

作者简介:

徐良洁,硕士研究生,主治医师,研究方向为心血管内科,E-mail为drxuliangjie@163.com。

基金项目:

镇江市社会发展基金项目(SH2014083);镇江市卫生科技重点项目(SH2015023);江苏大学临床医学专项基金项目(JDLCZX011)


Research on the Significance of Nuclear Factor of Activated T Cells c1 with Intravascular Ultrasound in Evaluating the Risk of Coronary Heart Disease
Author:
Affiliation:

Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China)

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    摘要:

    目的 以血管内超声(IVUS)分析为参照,探讨活化T细胞核因子c1(NFATc1)对不稳定性斑块的预测意义。方法 183例冠心病患者根据IVUS结果分为不稳定性斑块组(98例)和稳定性斑块组(85例),另选46例冠状动脉造影结果阴性患者为对照组。流式细胞术检测淋巴细胞内NFATc1表达水平,通过受试者工作曲线(ROC)分析其对不稳定性斑块的诊断意义。结果 冠心病患者NFATc1水平明显高于对照组,其中不稳定性斑块组NFATc1水平高于稳定性斑块组,NFATc1受试者工作曲线下面积为0.796,P=0.01,最佳界值平均荧光强度为17.5。结论 NFATc1是不稳定性斑块的活动性指标,能够评价冠心病风险,从而进一步预测急性冠状动脉事件的发生。

    Abstract:

    Aim To evaluate the significance of nuclear factor of activated T cells c1 (NFATc1) in diagnosing unstable plaques of coronary arteries referred to intravascular ultrasound (IVUS). Methods 183 patients with coronary heart disease (CHD) were divided into two groups of SA (with stable angina, 85 cases) and UA (with unstable angina, 98 cases) according to IVUS, another 46 patients without CHD confirmed by coronary angiography were taken as the controls. The expression of NFATc1 was measured by flow cytometry, then judged by creating the receiver operating characteristic curves (ROC). Results The expression of NFATc1 was significantly increased in patients with CHD, and the expression of NFATc1 in UA group was higher than that in SA group. Area under the ROC of NFATc1 was 0.796, P=0.01, the optimal operating point was 17.5. Conclusion Detection of NFATc1 would be useful for diagnosing unstable plaques of coronary arteries, and be better for evaluating the risk of CHD and predicting acute coronary events.

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引用本文

徐良洁,王中群,梁仪,周翠翠,樊廷攀,严金川.活化T细胞核因子c1检测联合血管内超声在冠心病风险评价中的作用[J].中国动脉硬化杂志,2016,24(11):1115~1118.

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  • 收稿日期:2016-08-10
  • 最后修改日期:2016-10-10
  • 在线发布日期: 2016-12-02