Arachidonic acid metabolites produced a large number of reactive oxygen species through a variety of ways,which promoted the inflammatory reaction and oxidative stress in vascular endothelial cells Inflammation reaction after percutaneous coronary intervention （PCI） is closely related to neointimal formation,excessive intimal hyperplasia leads to in-stent restenosis. However,this whole process involves the production of reactive oxygen species and oxidative stress. Based on metabonomics method,a series of distinctive arachidonic acid metabolites could be screened as a key marker predicting in-stent restenosis after PCI,which could provide new ideas for clinical research and treatment of in-stent restenosis.