AimTo explore the relationship between the lipoprotein lipase (LPL) -447C/G gene polymorphism and cerebral infarction in the elderly.MethodsThis was a case-control study, which enrolled 206 cases with cerebral infarction in the elderly and 203 elderly incerebrovascular disease controls.The genotype and allele frequencies of lipoprotein lipase-447C/G gene polymorphism were assayed by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP).The cerebral infarction patients were strictly diagnosed according to revise conference in the national fourth session of cerebrovascular disease.The basic document object of study was collection through questionnaire interview.ResultsThe LPL-447C/G genotype and allele distribution in the cerebral infarction group was CC 83.98%, CG+GG 16.02% and C 91.75%, G 8.25% respectively.The distribution in control group was CC 81.77%, CG+GG 18.23% and C 90.89%, G 9.11% respectively.There was no significant difference in LPL-447C/G allele and genotype distribution between the cerebral infarction group and the control group (p＞0.05).There was no significant difference detected in blood pressure level and blood lipids level between various genotypes (p＞0.05).Cerebral infarction multi-factor regression equation indicated primary hazard factors included smoking history, diabetes history and family history.Conclusions(1)LPL-447C/G gene polymorphism is not significantly associated with cerebral infarction in elderly.(2)LPL-447C/G gene polymorphism is not significantly associated with blood lipids level, blood pressure level in elderly.