AimTo examine the changes of blood pressure and brachial-ankle pulse wave velocity(BaPWV) in hypertensive patients who took amlodipine to treat hypertension.MethodsEighty male hypertensive patients were divided into two groups, one group was smokers,the other was nonsmokers,they all received amlodipine（5 mg/d） to treat hypertension, twelve weeks later, the changes of blood pressure and BaPWV were examined.ResultsThe efficiency of the two groups was 55.0% and 57.5% respectively, there was no differences between them.Before treatment, the BaPWV of smoking group was much higher than nonsmoking group（p<0.05）.There was no difference in the BaPWV of smoking group after antihypertensive therapy, but the BaPWV of nonsmoking group decreased distinctly after treatment（p<0.05）.ConclusionSmoking has no influence on antihypertensive therapy of calcium channel blocker amlodipine, but smoking increases the arterial stiffness in hypertensive patients, and reduces improvement of arterial stiffness in hypertensive patients who receive amlodipine.