Aim To compare the dynamic changes of neuroendocrine hormone levels on different treatment groups,in order to understand the angiotensin converting enzyme inhibitor and β-receptor blockers' effect on neuroendocrine hormone after valve replacement. Methods 60 patients were randomly divided into A,B,C groups,and were given different drugs after treatment.We took blood samples in the preoperative and different time of postoperation to determine plasma level of angiotensinⅡ,atrial natriuretic polypeptide,aldosterone. Results After valve replacement surgery,plasma angiotensinⅡ,atrial natriuretic polypeptide,aldosterone concentrations at all time measured compared with the preoperative levels had no significant differences in A group.But in B group and C group,compared with the preoperative and postoperative 1 week the plasma atrial natriuretic polypeptide concentrations had no significant change,plasma atrial natriuretic polypeptide concentrations measured in postoperative 2 weeks started to decline,plasma aldosterone concentrations started to decline until 4 weeks after operation;until postoperative 16 weeks the plasma angiotensinⅡ concentrations in B group had a significant decrease;and in C group the plasma angiotensinⅡ concentrations had significant decrease in 8 weeks after operation.Compared with B group and C group,the decreased level of plasma angiotensinⅡ,aldosterone concentrations after operation had no significant difference,but the decreased level of plasma atrial natriuretic polypeptide concentrations in C group was better than B group. Conclusion Patients after mechanical heart valve replacement surgery with routine cardiocinetic,diuretic therapy,and in addition supplemented angiotensin converting enzyme inhibitor and/or β-blocker treatment can effectively reduce the neuroendocrine hormone levels.