Prominent Roles of the Renin Angiotensin System in Atherosclerosis
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Prominent Roles of the Renin Angiotensin System in Atherosclerosis
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    摘要:

    The renin angiotensin system (RAS) is emerging as a prominent factor in the development of experimental atherosclerosis. We have previously demonstrated that the RAS is profoundly activated in hypercholesterolemia. This was demonstrated in LDLR-/-mice fed a saturated fat enriched diet and manifested as increased plasma concentrations of angiotensinogen and angiotensin peptides; especially angiotensin Ⅱ(AngⅡ).

    Abstract:

    The renin angiotensin system (RAS) is emerging as a prominent factor in the development of experimental atherosclerosis. We have previously demonstrated that the RAS is profoundly activated in hypercholesterolemia. This was demonstrated in LDLR-/-mice fed a saturated fat enriched diet and manifested as increased plasma concentrations of angiotensinogen and angiotensin peptides; especially angiotensin Ⅱ(AngⅡ).

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DebraL. Rateri, AlanDaugherty. Prominent Roles of the Renin Angiotensin System in Atherosclerosis[J].中国动脉硬化杂志,2009,17(7):573.

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