Aim Discuss the relation between vascular endothelium function,body composition and glucose metabolism in middleaged patients with impaired glucose tolerance.Methods Adopt the Philips IU-22 color Doppler ultrasound diagnostic system to detect vascular endothelium function,body composition and glucose metabolism indexes,and process a statistic analysis.Result(1) The rate of impaired glucose tolerance group to catch coronary heart disease,the positive rate of diabetes family history and family history in cardiovascular disease,are all obviously higher than the normal glucose tolerance group.(2)Compared to the normal glucose tolerance group,the BMI,BF%,waist circumference and 2-hour postprandial blood glucose of the impaired glucose tolerance group show significant difference,while the WHR and Fasting blood glucose are obviously higher.There is no significant difference in the SBP and DBP between two groups.(3)There is significant difference in the brachial arterial Dia-P% between two groups,while the brachial arterial internal diameter and Dia-N% show no significant difference.(4)The Dia-P% of middleaged impaired glucose tolerance patients is related the OGTT2h blood glucose.(5) The multivariate successive regression equation of Dia-P% in the middleaged impaired glucose tolerance patients show a predictor variable:OGTT2h blood glucose.Conclusion Brachial arterial vasodilation dysfunction exists in the middleaged impaired glucose tolerance patients,and the indexes of body composition and glucose metabolism change.Meanwhile,the abnormality of insulin resistance and OGTT2h blood glucose play an important role in the brachial arterial vasodilation dysfunction of middleaged IGT patients.