Aim To investigate the relationships between apolipoprotein E gene polymorphism and the occurrence of coronary heart disease (CHD). Methods The distributions of the Hha Ⅰ polymorphisms of the apolipoprotein E gene and blood lipids levels were determined among 132 Chinese subjects in relation to circulating lipids and coronary angiography. Results The control group had higher apolipoprotein E ε2 frequencies than the CHD group (p<0.001) and the apolipoprotein E gene alleles were associated with the plasma levels of lipids and lipoproteins (all p<0.05). ε2 was significantly correlated with CHD (p<0.001). Conclusion The results suggest that the apolipoprotein E gene polymorphism do have influence on circulating levels of lipids and lipoproteins and individuals with apolipoprotein E ε2 are likely to have a reduced risk of developing CHD.
[2]Bennet, Anna M.; Di Angelantonio, Emanuele; Ye, Zheng; Wensley, Frances; Dahlin, Anette; Ahlbom, Anders; Keavney, Bernard; Collins, Rory; Wiman, Bjorn; de Faire, Ulf; Danesh, John.Association of Apolipoprotein E Genotypes With Lipid Levels and Coronary Risk[J].The Journal of the American Medical Association,2007,298(11):1300-1311.