Aim To explore the effects of remedy-given insulin with a different dosage on the onset of coronary events in middle aged type-2 diabetes mellitus. Methods 53 middle-aged type-2 diabetes mellitus cases who were received insulin treatment with coronary heart disease were processed with insulin and peptic C measure and angiography. The coronary lesions and involved vessel score were repectively analysed using linea regression study. And another 32 type-2 diabetes mellitus without insulin regimen were placed in control group. Samples were analyzed with immunoreactiveinsulin and peptides C. Correlation between these variety scores for coronary lesions and 3 insulin sensitivity parameters was respectively obtained using linear regression analysis, and the stepwise regression analysis was used to assess dependence of associations. Results Serum insulin levels in coronary events group was significantly higher than those in control group. Most patients in coronary group consumed insulin more than 30 IU each day. Insulin and peptide C in coronary group was correlated with coronary lesion score or diseased vessel score. And the correlation was still significant with the insulin consumed consistance. Stepwise regression analysis showed that insulin and peptide C were independently correlated with the severity of coronary lesions. Conclusions The severity of coronary lesions was positively correlated with insulin and peptide C. Remedy-given hyperinsulinimia is only independently correlated with coronary events trigger in those type-2 diabetes mellitus. There might be certain association in the acute pathophysiology process of coronary lesion events.