Aim To determine the relationship between hyper uricemia and coronar y artery disease (CAD). Methods Serum concentrat ion of uric acid was measured and other biochemical assessments were made at a fasting state in 2 009 patients who have undergone coronary angiography. Results S erum uric acid level was significantly higher in CAD group than in normal corona ry group(369±97 mmol/L vs. 356±94 mmol/L, p<0.01). Uni var iable analysis with Mantel Haenszel Chi test in dicated that hyperuricemia had statistically significant relation with CAD ( χ 2 MH =4.364, Or=1.24, P=0.037). Despite similar mean value of serum uric acid level between acute myocardial infarction (AMI) and nor mal coronary groups, the number of patients with abnormal serum uric acid level was greater in the former than in the latter (p<0.05). Logistic regression analysis with control of other covariables showed a significant rela tionship between plasma uric acid level and CAD (χ 2 wald =4.76, P=0.0292, Or=0.999) and AMI (χ 2 wald =23.48,P= 0.0001,Or= 1.004). Conclusions Serum uric acid level had a strong relationship with the i ncidence of CAD. This relation was further enhanced when hyperuricemia is associ ated with diabetes mellitus and cigarette smoking.