Aging is one of the important risk factors of cardiovascular disease. With the rapid aging process in the world, the morbidity and mortality of patients with cardiovascular aging diseases have also increased significantly. Non-coding RNA provides a new molecular perspective for exploring cardiovascular aging diseases. Many studies have shown that non-coding RNA plays an important role in cardiovascular aging. The purpose of this review is to elucidate the role and progress of non-coding RNA in the regulation of cardiovascular aging, and to provide new therapeutic strategies for cardiovascular aging diseases.