Wnt signaling pathway regulates a variety of biological behaviors during embryonic development, including cell proliferation, apoptosis, cell polarity and organogenesis, and plays an important role in embryonic development.In an adult, it is thought to be silent. However, recent evidences show that Wnt signaling is reactivated in many biological processes and disease. It is involved in metabolism, inflammation, tumor and other diseases. Meanwhile, the signaling pathway regulates bone homeostasis, promotes osteoblast differentiation, induces bone formation, and is closely related to the development of atherosclerosis and vascular calcification. This review focuses on the effects of continuous activation of this signaling in endothelial dysfunction, inflammation, smooth muscle cell proliferation, and promotion of atherosclerosis and vascular calcification.