Myocardial infarction (MI) and its concomitant malignant arrhythmia, pathological ventricular remodeling and other complications are seriously harmful to human health. At present, drug therapy is the main strategy to stabilize plaque and reduce myocardial ischemia-reperfusion injury. Recent studies have shown that nano-drug delivery has great potential to benefit targeted therapy and enhance the safety and efficacy of drug treatment. This paper summarizes the present development of nano-drug delivery, and reviews the prospects of the treatment of myocardial infarction and its complications.